Hippo-YAP1/TAZ信号通路在心脏发育、疾病及再生中的分子机制
Molecular Mechanism of Hippo-YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration.
作者信息
Chen Xiaoqing, Li Yilang, Luo Jiandong, Hou Ning
机构信息
Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Guangzhou Institute of Cardiovascular Disease, Guangzhou Key Laboratory of Cardiovascular Disease, and The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
出版信息
Front Physiol. 2020 Apr 23;11:389. doi: 10.3389/fphys.2020.00389. eCollection 2020.
The Hippo-YAP1/TAZ pathway is a highly conserved central mechanism that controls organ size through the regulation of cell proliferation and other physical attributes of cells. The transcriptional factors Yes-associated protein 1 (YAP1) and PDZ-binding motif (TAZ) act as downstream effectors of the Hippo pathway, and their subcellular location and transcriptional activities are affected by multiple post-translational modifications (PTMs). Studies have conclusively demonstrated a pivotal role of the Hippo-YAP1/TAZ pathway in cardiac development, disease, and regeneration. Targeted therapeutics for the YAP1/TAZ could be an effective treatment option for cardiac regeneration and disease. This review article provides an overview of the Hippo-YAP1/TAZ pathway and the increasing impact of PTMs in fine-tuning YAP1/TAZ activation; in addition, we discuss the potential contributions of the Hippo-YAP1/TAZ pathway in cardiac development, disease, and regeneration.
Hippo-YAP1/TAZ信号通路是一种高度保守的核心机制，通过调节细胞增殖和细胞的其他物理属性来控制器官大小。转录因子Yes相关蛋白1（YAP1）和PDZ结合基序（TAZ）作为Hippo信号通路的下游效应器，它们的亚细胞定位和转录活性受到多种翻译后修饰（PTM）的影响。研究已确凿证明Hippo-YAP1/TAZ信号通路在心脏发育、疾病和再生中起关键作用。针对YAP1/TAZ的靶向治疗可能是心脏再生和疾病的有效治疗选择。本文综述概述了Hippo-YAP1/TAZ信号通路以及PTM在微调YAP1/TAZ激活方面日益增加的影响；此外，我们还讨论了Hippo-YAP1/TAZ信号通路在心脏发育、疾病和再生中的潜在作用。
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