Jafarzadeh Leila, Masoumi Elham, Fallah-Mehrjardi Keyvan, Mirzaei Hamid Reza, Hadjati Jamshid
Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Front Immunol. 2020 Apr 22;11:702. doi: 10.3389/fimmu.2020.00702. eCollection 2020.
CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific strategies that can be employed to overcome intrinsic and extrinsic barriers to CAR T cell persistence. We also offer our viewpoint on how growing use of CAR T cells in various cancers may require modifications in the intrinsic and extrinsic survival signals of CAR T cells. We anticipate these amendments will additionally provide the rationales for generation of more persistent, and thereby, more effective CAR T cell treatments. CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific strategies that can be employed to overcome intrinsic and extrinsic barriers to CAR T cell persistence. We also offer our viewpoint on how growing use of CAR T cells in various cancers may require modifications in the intrinsic and extrinsic survival signals of CAR T cells. We anticipate these amendments will additionally provide the rationales for generation of more persistent, and thereby, more effective CAR T cell treatments.
嵌合抗原受体（CAR）T细胞的特性，如持久性和功能性，在决定癌症免疫治疗的结果中起着重要作用。尽管具有完全的功能性，但已表明CAR T细胞的持久性差会限制有效的抗肿瘤免疫反应。在此，我们概述了可用于克服CAR T细胞持久性的内在和外在障碍的具体策略。我们还就CAR T细胞在各种癌症中越来越多的应用可能如何需要改变CAR T细胞的内在和外在生存信号提出了我们的观点。我们预计这些修正还将为产生更持久、从而更有效的CAR T细胞治疗提供理论依据。嵌合抗原受体（CAR）T细胞的特性，如持久性和功能性，在决定癌症免疫治疗的结果中起着重要作用。尽管具有完全的功能性，但已表明CAR T细胞的持久性差会限制有效的抗肿瘤免疫反应。在此，我们概述了可用于克服CAR T细胞持久性的内在和外在障碍的具体策略。我们还就CAR T细胞在各种癌症中越来越多的应用可能如何需要改变CAR T细胞的内在和外在生存信号提出了我们的观点。我们预计这些修正还将为产生更持久、从而更有效的CAR T细胞治疗提供理论依据。
