Parsi Meghana, Daniel Catherine
Internal Medicine, Crozer-Chester Medical Center, Upland, USA.
Internal Medicine, Baylor College of Medicine, Houston, USA.
Cureus. 2020 Apr 7;12(4):e7570. doi: 10.7759/cureus.7570.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare drug-induced hypersensitivity reaction that manifests with a variety of signs and symptoms. It is an important condition that must be recognized by all physicians because if untreated, it can be fatal. There are a variety of medications that are responsible for this condition. The liver, lungs, and kidneys are commonly affected, with the involvement of the gastrointestinal tract being very rare; only a few cases are reported worldwide. We are presenting a case of lamotrigine-induced DRESS syndrome manifesting as colitis. A 32-year-old female presented with diarrhea, two weeks after the initiation of lamotrigine. Her condition worsened with the development of a generalized rash and bloody diarrhea. Further investigations revealed that she likely had a drug reaction secondary to lamotrigine. Fortunately, prompt initiation of systemic steroids led to the resolution of her symptoms.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种罕见的药物诱导的超敏反应，表现为多种体征和症状。这是所有医生都必须认识到的一种重要病症，因为如果不治疗，可能会致命。有多种药物可导致这种病症。肝脏、肺和肾脏通常会受到影响，胃肠道受累非常罕见；全球仅报告了少数病例。我们报告一例表现为结肠炎的拉莫三嗪诱导的DRESS综合征病例。一名32岁女性在开始服用拉莫三嗪两周后出现腹泻。随着全身性皮疹和血性腹泻的出现，她的病情恶化。进一步检查显示她可能继发于拉莫三嗪的药物反应。幸运的是，及时开始使用全身性类固醇导致她的症状得到缓解。
