儿童拉莫三嗪诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征：一例报告及文献综述
Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review.
作者信息
Lin Chien-Heng, Lin Sheng-Shing, Hong Syuan-Yu, Chen Chieh-Ho, Chou I-Ching
机构信息
Division of Pediatric Pulmonology, China Medical University Children's Hospital, Taichung 404327, Taiwan.
Department of Biomedical Imaging and Radiological Science, College of Medicine, China Medical University, Taichung 404328, Taiwan.
出版信息
Children (Basel). 2021 Nov 19;8(11):1063. doi: 10.3390/children8111063.
Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in a stable condition. Anticonvulsant drugs such as lamotrigine are among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.
拉莫三嗪是一种重要的抗惊厥药物。然而，其使用受到潜在危及生命的皮肤反应风险的限制，例如伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）。在此，我们报告一例7岁6个月大的癫痫女童病例，该女童在拉莫三嗪治疗2周后出现皮疹并伴有呼吸困难，最终被诊断为DRESS。停用致病药物并开始使用全身性糖皮质激素后，DRESS症状得到缓解，患者病情稳定出院。拉莫三嗪等抗惊厥药物是诱发儿童DRESS的因素之一。当患者在开始使用抗惊厥药物后出现皮疹和全身器官受累时，不应忽视DRESS这一诊断，免疫抑制药物应被视为治疗DRESS患者的一种选择。
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