Zhang Caizhe, Hong Kui
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.
Front Bioeng Biotechnol. 2020 Apr 24;8:347. doi: 10.3389/fbioe.2020.00347. eCollection 2020.
Terpenoids are a large family of natural products with remarkable diverse biological functions, and have a wide range of applications as pharmaceuticals, flavors, pigments, and biofuels. Synthetic biology is presenting possibilities for sustainable and efficient production of high value-added terpenoids in engineered microbial cell factories, using and which are identified as well-known industrial workhorses. They also provide a promising alternative to produce non-native terpenes on account of available genetic tools in metabolic engineering and genome editing. In this review, we summarize the recent development in terpenoids production by synthetic biology approaches.
萜类化合物是一类具有显著多样生物功能的天然产物，作为药物、香料、色素和生物燃料具有广泛的应用。合成生物学为利用被公认为著名工业主力的大肠杆菌和酿酒酵母在工程化微生物细胞工厂中可持续和高效地生产高附加值萜类化合物提供了可能性。由于代谢工程和基因组编辑中可用的遗传工具，它们也为生产非天然萜烯提供了一种有前景的替代方法。在这篇综述中，我们总结了通过合成生物学方法生产萜类化合物的最新进展。
