Wang Chonglong, Liwei Mudanguli, Park Ji-Bin, Jeong Seong-Hee, Wei Gongyuan, Wang Yujun, Kim Seon-Won
School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Division of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, Jinju, South Korea.
Front Microbiol. 2018 Oct 12;9:2460. doi: 10.3389/fmicb.2018.02460. eCollection 2018.
Terpenoids, also called isoprenoids, are a large and highly diverse family of natural products with important medical and industrial properties. However, a limited production of terpenoids from natural resources constrains their use of either bulk commodity products or high valuable products. Microbial production of terpenoids from and yeasts provides a promising alternative owing to available genetic tools in pathway engineering and genome editing, and a comprehensive understanding of their metabolisms. This review summarizes recent progresses in engineering of industrial model strains, and yeasts, for terpenoids production. With advances of synthetic biology and systems biology, both strains are expected to present the great potential as a platform of terpenoid synthesis.
萜类化合物，也称为类异戊二烯，是一类庞大且高度多样的天然产物家族，具有重要的医学和工业特性。然而，从自然资源中获取的萜类化合物产量有限，这限制了它们在大宗商品或高价值产品中的应用。由于在途径工程和基因组编辑方面有可用的遗传工具，以及对其代谢的全面了解，利用细菌和酵母进行萜类化合物的微生物生产提供了一种有前景的替代方法。本综述总结了在工程改造工业模式菌株细菌和酵母以生产萜类化合物方面的最新进展。随着合成生物学和系统生物学的发展，预计这两种菌株都具有作为萜类化合物合成平台的巨大潜力。
