Nacarelli Timothy, Zhao Bo, Hao Xue, Zhang Rugang
Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Mol Cell Oncol. 2020 Feb 23;7(3):1690923. doi: 10.1080/23723556.2019.1690923. eCollection 2020.
We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in -mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in -mutated cancers.
我们最近发现，含AT丰富相互作用结构域蛋白1A（ARID1A）通过调节黏连蛋白亚基基质抗原1（STAG1）来保护端粒黏连。ARID1A失活会导致有丝分裂缺陷，并对严重染色体畸变产生负选择作用，从而在ARID1A突变的癌症中维持基因组稳定性。这些发现解释了由ARID1A失活引起的有丝分裂缺陷与ARID1A突变癌症中缺乏基因组不稳定性之间长期存在的矛盾。
