Breithardt G, Zeitter J, Moritz K, Bluschke V, Lehmann H, Borggrefe M
Medizinische Klinik und Poliklinik, Westfälische Wilhelms-Universität Münster.
Z Kardiol. 1988 Oct;77(10):642-8.
48 asymptomatic alcoholics (mean age 31.2 years) with an average daily alcohol consumption of 287 g were studied about 45 h (mean) after the last ingestion of alcohol. M-mode echocardiography and 24-h long-term ECG recordings were performed. 24 of these patients were restudied after a mean of 12 days of abstinence using long-term ECG recording. All patients were in sinus rhythm. 44 of 48 patients demonstrated supraventricular premature beats. In three patients, there were ventricular pairs (1/24 h). Two further patients had ventricular triplets (1/24 h). Echocardiography demonstrated a significant enlargement of left atrial dimensions (LA: 39 +/- 3.8 mm), of the diameter of the left ventricular posterior wall (10 +/- 4.1 mm), and of the interventricular septum (12 +/- 1.7 mm) compared to control data in 24 'normals'. In addition, there was a significant increase in the derived left ventricular mass index (292 +/- 48.2 g). Left ventricular enddiastolic diameter was not significantly different. Laboratory tests showed pathologically elevated values of SGOT, SGPT, and gamma-GT whereas serum potassium was normal. During restudy of the long-term ECG after 12 days, complex ventricular arrhythmias were no longer detectable. In six patients, echocardiography was repeated after a mean of 110 days of abstinence. Three of these patients had had marginal left ventricular fractional shortening during the first study which was normalized at the repeat study. Our results show some degree of left ventricular dysfunction in some chronic alcoholics without clinical overt heart failure.
对48名无症状酗酒者（平均年龄31.2岁）进行了研究，这些人平均每日酒精摄入量为287克，在最后一次摄入酒精约45小时（平均）后接受检查。进行了M型超声心动图检查和24小时动态心电图记录。其中24名患者在平均戒酒12天后再次接受动态心电图记录检查。所有患者均为窦性心律。48名患者中有44名出现室上性早搏。3名患者出现室性成对早搏（每24小时1次）。另有2名患者出现室性三联律（每24小时1次）。与24名“正常”对照者的数据相比，超声心动图显示左心房内径（LA：39±3.8毫米）、左心室后壁直径（10±4.1毫米）和室间隔厚度（12±1.7毫米）均显著增大。此外，推算的左心室质量指数显著增加（292±48.2克）。左心室舒张末期直径无显著差异。实验室检查显示谷草转氨酶、谷丙转氨酶和γ-谷氨酰转移酶值病理性升高，而血清钾正常。在戒酒12天后再次进行动态心电图检查时，不再能检测到复杂的室性心律失常。6名患者在平均戒酒110天后重复进行了超声心动图检查。其中3名患者在首次检查时左心室缩短分数处于临界值，在重复检查时恢复正常。我们的结果表明，一些慢性酗酒者存在一定程度的左心室功能障碍，但无明显临床心力衰竭症状。
