癌症中药理基因组相互作用的复杂性。
Complexities of pharmacogenomic interactions in cancer.
作者信息
Khanna Kum Kum, Duijf Pascal H G
机构信息
QIMR Berghofer Medical Research Institute, Herston, Australia.
Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
出版信息
Mol Cell Oncol. 2020 Mar 19;7(3):1735910. doi: 10.1080/23723556.2020.1735910. eCollection 2020.
Genetic and genomic alterations drive cancer development. However, they may also constitute vulnerabilities, including increased drug sensitivity, which could be harnessed for precision medicine purposes. We discuss the highly complex pharmacogenomic interactions that are beginning to be disentangled and hurdles that may need to be overcome before cancer patients could benefit.
遗传和基因组改变推动癌症发展。然而，它们也可能构成弱点，包括增加药物敏感性，这可用于精准医疗目的。我们讨论了开始被理清的高度复杂的药物基因组学相互作用以及在癌症患者受益之前可能需要克服的障碍。
Zotero 插件