Metformin disposition-A 40-year-old mystery.
作者信息
Tucker Geoffrey T, Wesolowski Carl A
机构信息
Department of Human Metabolism, Medical and Biological Sciences, University of Sheffield, Sheffield, UK.
Department of Medical Imaging, Royal University Hospital, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
出版信息
Br J Clin Pharmacol. 2020 Aug;86(8):1452-1453. doi: 10.1111/bcp.14320. Epub 2020 May 11.
Abstract
摘要
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本文引用的文献
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Comparison of the gamma-Pareto convolution with conventional methods of characterising metformin pharmacokinetics in dogs.比较伽马-帕累托卷积与常规方法在狗体内表征二甲双胍药代动力学的特点。
J Pharmacokinet Pharmacodyn. 2020 Feb;47(1):19-45. doi: 10.1007/s10928-019-09666-z. Epub 2019 Dec 21.
2
Biodegradation of metformin and its transformation product, guanylurea, by natural and exposed microbial communities.天然和暴露微生物群落对二甲双胍及其转化产物胍基脲的生物降解作用。
Ecotoxicol Environ Saf. 2019 Oct 30;182:109414. doi: 10.1016/j.ecoenv.2019.109414. Epub 2019 Jul 10.
3
Pharmacokinetic interaction between itraconazole and metformin in rats: competitive inhibition of metabolism of each drug by each other via hepatic and intestinal CYP3A1/2.伊曲康唑和二甲双胍在大鼠体内的药代动力学相互作用：通过肝和肠道 CYP3A1/2，彼此竞争性抑制了各自药物的代谢。
Br J Pharmacol. 2010 Oct;161(4):815-29. doi: 10.1111/j.1476-5381.2010.00913.x.
4
Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin.酶诱导剂和抑制剂对大鼠体内二甲双胍药代动力学的影响：CYP2C11、2D1和3A1/2参与二甲双胍的代谢
Br J Pharmacol. 2006 Oct;149(4):424-30. doi: 10.1038/sj.bjp.0706875. Epub 2006 Aug 29.
5
Metformin kinetics in healthy subjects and in patients with diabetes mellitus.健康受试者和糖尿病患者体内二甲双胍的动力学
Br J Clin Pharmacol. 1981 Aug;12(2):235-46. doi: 10.1111/j.1365-2125.1981.tb01206.x.
6
Measurement of the renal clearance of drugs.药物肾清除率的测定。
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7
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8
Determination of metformin in biological samples.生物样品中二甲双胍的测定
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9
Pharmacokinetics of metformin after intravenous and oral administration to man.二甲双胍在人体静脉注射和口服后的药代动力学。
Eur J Clin Pharmacol. 1979 Sep;16(3):195-202. doi: 10.1007/BF00562061.
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