Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany.
Internal Medicine, University Hospital Carl Gustav Carus, Dresden, Germany.
Pharmacopsychiatry. 2020 Sep;53(5):235-236. doi: 10.1055/a-1167-3267. Epub 2020 May 11.
Lithium has been the gold standard in the long-term treatment of bipolar disorder for more than 40 years 1. Due to a narrow therapeutic index lithium intoxication still is a common but potentially avoidable clinical problem 2. The possibility of SILENT-syndrome (syndrome of irreversible lithium-effectuated neurotoxicity) illustrates that prevention and optimal treatment of lithium intoxication is vitally important 3.
锂盐已成为治疗双相障碍的金标准，应用于临床已有 40 多年 1。由于治疗指数窄，锂中毒仍然是一种常见但可以避免的临床问题 2。SILENT 综合征（锂毒性导致的不可逆转的神经毒性综合征）的发生提示，预防和优化锂中毒的治疗至关重要 3。
