Liu M M, Shi J
Shanxi Medical University School and Hospital of Stomatology,Taiyuan 030001, China.
Department of Oral Medicine, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2020 May 9;55(5):353-356. doi: 10.3760/cma.j.cn112144-20190522-00214.
Nitric oxide (NO) is a short-lived free radical which is not only involved in regulating many physiological processes of the body, but also closely related to many diseases. Nitric oxide synthase (NOS) is the key enzyme for NO production. NOS exists as three distinct isoforms, the endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS). It has been found that nNOS and eNOS were expressed in normal pulp tissues, periodontal tissues and salivary glands, and the NO produced from nNOS and eNOS was involved in their physiological functions. NO and iNOS are involved in the occurrence and development of pulpitis, periodontitis, salivary gland disease and oral cancer. This review focuses on the physiological and pathological effects of NO and different subtypes of NOS in oral cavity.
一氧化氮（NO）是一种半衰期较短的自由基，它不仅参与调节身体的许多生理过程，还与许多疾病密切相关。一氧化氮合酶（NOS）是产生NO的关键酶。NOS以三种不同的同工型存在，即内皮型NOS（eNOS）、神经元型NOS（nNOS）和诱导型NOS（iNOS）。研究发现，nNOS和eNOS在正常牙髓组织、牙周组织和唾液腺中表达，由nNOS和eNOS产生的NO参与了它们的生理功能。NO和iNOS参与了牙髓炎、牙周炎、唾液腺疾病和口腔癌的发生和发展。本文综述了NO及NOS不同亚型在口腔中的生理和病理作用。
