白细胞介素-8-251A/T 多态性与结核病风险的关联：一项荟萃分析。
Association between interleukin-8 -251A/T polymorphism and the risk of tuberculosis: A meta-analysis.
机构信息
Department of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, China.
出版信息
J Int Med Res. 2020 May;48(5):300060520917877. doi: 10.1177/0300060520917877.
OBJECTIVE
The relationship between interleukin-8 () -251A/T polymorphism and tuberculosis (TB) risk remains controversial. Therefore, the present meta-analysis was performed by retrieving relevant studies from the available literature.
METHODS
We comprehensively searched three databases to identify eligible literature on the relationship of -251A/T polymorphism with TB risk, calculated pooled odds ratios (OR) with 95% confidence intervals (CI), and subsequent evaluated the heterogeneity and publication bias.
RESULTS
We found that -251A/T polymorphism increased TB risk (AA vs. TT: OR = 2.86, 95%CI: 1.46-5.60; AT vs. TT: OR = 1.64, 95%CI: 1.15-2.34; dominant model: OR = 1.88, 95%CI: 1.24-2.86; recessive model: OR = 1.77, 95%CI: 1.17-2.69). Subgroup analyses based on race revealed that the -251A/T polymorphism might be associated with the risk of TB in African but not Asian individuals.
CONCLUSION
The -251A/T polymorphism might be related to the risk of TB. Nevertheless, large-scale studies should be performed to confirm the role of -251A/T polymorphism on TB risk.
目的
白细胞介素-8 (-251A/T) 多态性与结核病 (TB) 风险之间的关系仍存在争议。因此，本荟萃分析通过从现有文献中检索相关研究来进行。
方法
我们全面检索了三个数据库，以确定与 -251A/T 多态性与 TB 风险相关的合格文献，计算合并优势比 (OR) 及其 95%置信区间 (CI)，并随后评估异质性和发表偏倚。
结果
我们发现 -251A/T 多态性增加了 TB 风险 (AA 与 TT：OR=2.86，95%CI：1.46-5.60；AT 与 TT：OR=1.64，95%CI：1.15-2.34；显性模型：OR=1.88，95%CI：1.24-2.86；隐性模型：OR=1.77，95%CI：1.17-2.69)。基于种族的亚组分析表明，-251A/T 多态性可能与非洲人群而非亚洲人群的 TB 风险相关。
结论
-251A/T 多态性可能与 TB 风险相关。然而，应开展大规模研究来证实 -251A/T 多态性在 TB 风险中的作用。
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