Patai K, Balogh I
2nd Department of Obstetrics and Gynaecology, Semmelweis University Medical School, Budapest, Hungary.
Acta Chir Hung. 1988;29(4):315-21.
The prolonged effect of nickel chloride and cadmium chloride on the rat fetal myocardium was studied experimentally administered to the pregnant mother through a gastric tube in doses of 12.5 mg/b. wt. It could be demonstrated that, due to nickel administration, changes simulating cardiomyopathy and severe mitochondrial lesions developed and the number of collagenous fibres and glycogen granules accumulated, while as a result of cadmium chloride administration, changes were apparent mainly in the endothelial cells, but with simultaneous mitochondrial impairments, too. Nickel and cadmium are contained by cigarette smoke. Based on experimental studies, authors propose new arguments on the damaging effect of smoking of pregnant women.
通过胃管以12.5毫克/体重的剂量给怀孕母鼠经口灌胃，对氯化镍和氯化镉对大鼠胎儿心肌的长期影响进行了实验研究。结果表明，给予镍后，出现了模拟心肌病的变化和严重的线粒体损伤，胶原纤维和糖原颗粒数量增加；而给予氯化镉后，变化主要出现在内皮细胞中，但同时也伴有线粒体损伤。香烟烟雾中含有镍和镉。基于实验研究，作者提出了关于孕妇吸烟有害影响的新论据。
