脂质致死：小核仁 RNA 在代谢应激中的作用。
Death by lipids: The role of small nucleolar RNAs in metabolic stress.
机构信息
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
出版信息
J Biol Chem. 2020 Jun 19;295(25):8628-8635. doi: 10.1074/jbc.AW120.011105. Epub 2020 May 11.
Abstract
Excess fatty acid accumulation in nonadipose tissues leads to cell dysfunction and cell death that is linked to the pathogenesis of inherited and acquired human diseases. Study of this process, known as lipotoxicity, has provided new insights into the regulation of lipid homeostasis and has revealed new molecular pathways involved in lipid-induced cellular stress. The discovery that disruption of specific small nucleolar RNAs protects against fatty acid-induced cell death and remodels metabolism opens new opportunities for understanding how nutrient signals influence cellular and systemic metabolic homeostasis through RNA biology.
摘要
过量的脂肪酸在非脂肪组织中的积累会导致细胞功能障碍和细胞死亡，这与遗传性和获得性人类疾病的发病机制有关。对这一过程的研究，即脂毒性，为脂质稳态的调节提供了新的见解，并揭示了脂质诱导的细胞应激中涉及的新的分子途径。破坏特定的小核仁 RNA 可以防止脂肪酸诱导的细胞死亡并重塑代谢的发现，为理解营养信号如何通过 RNA 生物学影响细胞和全身代谢稳态开辟了新的机会。
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