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本文引用的文献

1
snoDB: an interactive database of human snoRNA sequences, abundance and interactions.snoDB：一个人类 snoRNA 序列、丰度和相互作用的交互式数据库。
Nucleic Acids Res. 2020 Jan 8;48(D1):D220-D225. doi: 10.1093/nar/gkz884.
2
A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.单个 H/ACA 小核仁 RNA 介导致癌性 RAS 下游的肿瘤抑制。
Elife. 2019 Sep 3;8:e48847. doi: 10.7554/eLife.48847.
3
Disturbed Fatty Acid Oxidation, Endoplasmic Reticulum Stress, and Apoptosis in Left Ventricle of Patients With Type 2 Diabetes.2 型糖尿病患者左心室中脂肪酸氧化、内质网应激和细胞凋亡紊乱。
Diabetes. 2019 Oct;68(10):1924-1933. doi: 10.2337/db19-0423. Epub 2019 Aug 7.
4
During Adipocyte Remodeling, Lipid Droplet Configurations Regulate Insulin Sensitivity through F-Actin and G-Actin Reorganization.在脂肪细胞重塑过程中，脂滴结构通过肌动蛋白纤维的重组调节胰岛素敏感性。
Mol Cell Biol. 2019 Sep 27;39(20). doi: 10.1128/MCB.00210-19. Print 2019 Oct 15.
5
Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.探究饱和脂肪酸引起的脂毒性对全球细胞反应的影响。
Mol Cell. 2019 Apr 4;74(1):32-44.e8. doi: 10.1016/j.molcel.2019.01.036. Epub 2019 Mar 4.
6
CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.CHP1 通过激活 GPAT4 调控区隔性甘油脂质合成。
Mol Cell. 2019 Apr 4;74(1):45-58.e7. doi: 10.1016/j.molcel.2019.01.037. Epub 2019 Mar 4.
7
Long-range function of secreted small nucleolar RNAs that direct 2'--methylation.引导 2'--甲基化的分泌性小核仁 RNA 的长程功能。
J Biol Chem. 2018 Aug 24;293(34):13284-13296. doi: 10.1074/jbc.RA118.003410. Epub 2018 Jul 6.
8
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.证据表明 TLR4 不是饱和脂肪酸的受体，而是通过重新编程巨噬细胞代谢来介导脂质引起的炎症。
Cell Metab. 2018 May 1;27(5):1096-1110.e5. doi: 10.1016/j.cmet.2018.03.014. Epub 2018 Apr 19.
9
Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.下丘脑 Snord116 的缺失重现了普拉德-威利综合征的多食症。
J Clin Invest. 2018 Mar 1;128(3):960-969. doi: 10.1172/JCI97007. Epub 2018 Jan 29.
10
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.脂毒性心脏中的线粒体活性氧诱导 AKAP121、DRP1 和 OPA1 的翻译后修饰，从而促进线粒体分裂。
Circ Res. 2018 Jan 5;122(1):58-73. doi: 10.1161/CIRCRESAHA.117.311307. Epub 2017 Nov 1.

脂质致死：小核仁 RNA 在代谢应激中的作用。

Death by lipids: The role of small nucleolar RNAs in metabolic stress.

机构信息

Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA

出版信息

J Biol Chem. 2020 Jun 19;295(25):8628-8635. doi: 10.1074/jbc.AW120.011105. Epub 2020 May 11.

DOI:10.1074/jbc.AW120.011105
PMID:32393576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7307203/
Abstract

Excess fatty acid accumulation in nonadipose tissues leads to cell dysfunction and cell death that is linked to the pathogenesis of inherited and acquired human diseases. Study of this process, known as lipotoxicity, has provided new insights into the regulation of lipid homeostasis and has revealed new molecular pathways involved in lipid-induced cellular stress. The discovery that disruption of specific small nucleolar RNAs protects against fatty acid-induced cell death and remodels metabolism opens new opportunities for understanding how nutrient signals influence cellular and systemic metabolic homeostasis through RNA biology.

摘要

过量的脂肪酸在非脂肪组织中的积累会导致细胞功能障碍和细胞死亡，这与遗传性和获得性人类疾病的发病机制有关。对这一过程的研究，即脂毒性，为脂质稳态的调节提供了新的见解，并揭示了脂质诱导的细胞应激中涉及的新的分子途径。破坏特定的小核仁 RNA 可以防止脂肪酸诱导的细胞死亡并重塑代谢的发现，为理解营养信号如何通过 RNA 生物学影响细胞和全身代谢稳态开辟了新的机会。