Beaudoin Mélissa, Potvin Stéphane, Giguère Charles-Edouard, Discepola Sophie-Lena, Dumais Alexandre
Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Montreal, QC, Canada.
Faculty of Medicine, Department of Psychiatry and Addictology, Université de Montréal, Montreal, QC, Canada.
NPJ Schizophr. 2020 May 11;6(1):14. doi: 10.1038/s41537-020-0104-x.
Although recent studies have shown a moderately strong association between cannabis use and violence among people with severe mental disorders, the direction of this association has not been investigated prospectively in a population with schizophrenia. Therefore, this study aims to determine, using cross-lag models, whether a temporal relationship between cumulative cannabis use and violence exists in a population with schizophrenia. The authors reported findings covering an 18-month period from a randomized, double-blind clinical trial of antipsychotic medications for schizophrenia treatment. Among the 1460 patients enrolled in the trial, 965 were followed longitudinally. Although persistent cannabis use predicted subsequent violence, violence did not predict cannabis use. The relationship was therefore unidirectional and persisted when controlling for stimulants and alcohol use. Finally, a significant body of evidence suggests a link between persistent cannabis use and violence among people with mental illnesses. Studies to further investigate the mechanisms underlying this association should be conducted.
尽管最近的研究表明，在患有严重精神障碍的人群中，使用大麻与暴力行为之间存在适度的强关联，但这种关联的方向尚未在精神分裂症患者群体中进行前瞻性研究。因此，本研究旨在使用交叉滞后模型，确定在精神分裂症患者群体中，累积使用大麻与暴力行为之间是否存在时间关系。作者报告了一项为期18个月的研究结果，该研究来自一项用于精神分裂症治疗的抗精神病药物的随机双盲临床试验。在该试验招募的1460名患者中，有965名患者接受了纵向随访。虽然持续使用大麻可预测随后的暴力行为，但暴力行为并不能预测大麻的使用。因此，这种关系是单向的，在控制兴奋剂和酒精使用后依然存在。最后，大量证据表明，持续使用大麻与精神疾病患者的暴力行为之间存在联系。应该开展进一步研究以探究这种关联背后的机制。
