酶控制的 Janus 纳米机器，用于命令式双重和顺序释放。
An enzyme-controlled Janus nanomachine for on-command dual and sequential release.
机构信息
Nanosensors and Nanomachines Group, Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Madrid 28040, Spain.
出版信息
Chem Commun (Camb). 2020 Jun 14;56(47):6440-6443. doi: 10.1039/d0cc01234c. Epub 2020 May 12.
PMID:32393950
Abstract
A novel nanomachine for dual and sequential delivery of two different compounds was developed by grafting a thiol group and a pH sensitive β-cyclodextrin-based gate-like ensemble on acetylcholinesterase-modified Au-mesoporous silica Janus nanoparticles.
摘要
通过将巯基和 pH 敏感的β-环糊精基门控集装物接枝到乙酰胆碱酯酶修饰的 Au-介孔硅 Janus 纳米粒子上，开发了一种用于双重和顺序递送两种不同化合物的新型纳米机器。
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