Mohamed Isa Eleen Dayana, Ahmad Haslina, Abdul Rahman Mohd Basyaruddin, Gill Martin R
Department of Chemical and Environmental Engineering, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, Kuala Lumpur 54100, Malaysia.
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM Serdang 43000, Malaysia.
Pharmaceutics. 2021 Jan 24;13(2):152. doi: 10.3390/pharmaceutics13020152.
Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.
在过去几十年里，癌症治疗与疗法取得了显著的飞跃。然而，仍有一些病例无法通过手术切除，转移灶难以处理，且化疗和放疗会带来严重的副作用。因此，仍有必要寻找更有效、更具特异性的治疗方法。一种途径是利用基于纳米材料的药物递送载体（DDA）。2001年，介孔二氧化硅纳米颗粒（MSN）首次被用作药物递送载体，并在该领域受到了广泛关注。MSN之所以广受欢迎，是因为它们具有独特的性质，如可调节的颗粒和孔径、高比表面积和孔体积、易于功能化和表面修饰、高稳定性以及高效包裹载药分子的能力。本综述描述了MSN作为癌症治疗药物递送载体的最新进展。我们重点关注MSN的制备、药物递送载体开发中的挑战，以及MSN如何通过开发智能药物递送载体来解决这些问题。除此之外，MSN还被用作多功能药物递送载体，可用于癌症的诊断和治疗。总体而言，我们认为MSN为癌症的诊断和治疗都提供了光明的前景。
