Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400014, China.
Theranostics. 2022 Feb 28;12(6):2560-2579. doi: 10.7150/thno.70243. eCollection 2022.
In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the required standard of effectiveness, primarily owing to issues of drug resistance exhibited by cancer cells and inherent differences among the patients. In this regard, combination therapy offers advantages of synergistic mechanism, reduced drug dosage, and enhanced therapeutic effect, which can be effectively utilized for the treatment of cancer. However, different types of therapeutic agents exhibit different pharmacokinetic properties and action targets , which lead to uncontrollable concentration ratio of therapeutic agents at the lesion site. This in turn causes serious side effects and affects synergistic anticancer effect. Importantly, multifunctional co-delivery systems are characterized by good pharmacokinetic properties, ability to provide targeted delivery, and controlled release in response to tumor microenvironment. Such delivery systems are widely used for co-delivery of therapeutic agents, which further assist in obtaining better synergistic anticancer effect, and can be potentially used for clinical application. Multifunctional co-delivery systems often exhibit complex structures and construction process. Since cyclodextrin is characterized by self-assembly property, it is possible to quickly construct cyclodextrin-based multifunctional co-delivery systems, with convenience and flexibility. The application of cyclodextrin in the construction of multifunctional co-delivery systems for cancer therapy has gained immense attention in the past few years. The present study provided overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy.
在过去的几年中，药物传递系统被广泛用于提高化疗药物的溶解度、稳定性和药代动力学。然而，传统的传递系统未能达到所需的有效性标准，主要是由于癌细胞表现出的耐药性问题和患者之间固有的差异。在这方面，联合治疗具有协同机制、减少药物剂量和增强治疗效果的优势，可以有效地用于癌症治疗。然而，不同类型的治疗剂表现出不同的药代动力学特性和作用靶点，这导致治疗剂在病变部位的浓度比不可控。这反过来又会导致严重的副作用，并影响协同抗癌效果。重要的是，多功能共递药系统具有良好的药代动力学特性、靶向递药能力和对肿瘤微环境的控制释放能力。这些递药系统广泛用于共递药，有助于获得更好的协同抗癌效果，并有可能用于临床应用。多功能共递药系统通常具有复杂的结构和构建过程。由于环糊精具有自组装特性，因此可以快速构建基于环糊精的多功能共递药系统，具有方便性和灵活性。近年来，环糊精在构建癌症治疗多功能共递药系统中的应用受到了极大关注。本研究综述了近年来基于环糊精的多功能共递药系统在癌症协同治疗中的最新进展。
