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Eudragit® 聚合物在新型药物传递系统开发中的应用。

Expedition of Eudragit® Polymers in the Development of Novel Drug Delivery Systems.

机构信息

Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (C.G.) 495 009, India.

出版信息

Curr Drug Deliv. 2020;17(6):448-469. doi: 10.2174/1567201817666200512093639.

Abstract

Eudragit® polymer has been widely used in film-coating for enhancing the quality of products over other materials (e.g., shellac or sugar). Eudragit® polymers are obtained synthetically from the esters of acrylic and methacrylic acid. For the last few years, they have shown immense potential in the formulations of conventional, pH-triggered, and novel drug delivery systems for incorporating a vast range of therapeutics including proteins, vitamins, hormones, vaccines, and genes. Different grades of Eudragit® have been used for designing and delivery of therapeutics at a specific site via the oral route, for instance, in stomach-specific delivery, intestinal delivery, colon-specific delivery, mucosal delivery. Further, these polymers have also shown their great aptitude in topical and ophthalmic delivery. Moreover, available literature evidences the promises of distinct Eudragit® polymers for efficient targeting of incorporated drugs to the site of interest. This review summarizes some potential researches that are being conducted by eminent scientists utilizing the distinct grades of Eudragit® polymers for efficient delivery of therapeutics at various sites of interest.

摘要

尤特奇®聚合物已被广泛应用于薄膜包衣,以提高产品质量,优于其他材料(如虫胶或糖)。尤特奇®聚合物是通过丙烯酸和甲基丙烯酸的酯类合成得到的。在过去的几年中,它们在常规、pH 触发和新型药物传递系统的配方中显示出巨大的潜力,可包含广泛的治疗剂,包括蛋白质、维生素、激素、疫苗和基因。不同等级的尤特奇®聚合物已被用于通过口服途径在特定部位设计和传递治疗剂,例如,在胃特异性传递、肠道传递、结肠特异性传递、粘膜传递。此外,这些聚合物在局部和眼科传递方面也表现出了很强的适应能力。此外,现有文献证据表明,不同等级的尤特奇®聚合物有望将所包含的药物有效靶向到感兴趣的部位。本综述总结了一些杰出科学家正在进行的潜在研究,他们利用不同等级的尤特奇®聚合物,在各种感兴趣的部位进行有效的治疗剂传递。

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