Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea.
Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea.
Molecules. 2022 Sep 29;27(19):6439. doi: 10.3390/molecules27196439.
Although nicotinic acid (NA) has several clinical benefits, its potency cannot be fully utilized due to several undesirable side effects, including cutaneous flushing, GIT-associated symptoms, etc. To overcome such issues and improve the NA efficacy, a new inorganic-organic nanohybrids system was rationally designed. For making such a hybrid system, NA was intercalated into LDH through a coprecipitation technique and then coated with Eudragit S100 to make the final drug delivery system called Eudragit S100-coated NA-LDH. The as-made drug delivery system not only improved the NA release profile but also exhibited good bio-compatibility as tested on L929 cells. Such an inorganic-organic nanohybrid drug delivery agent is expected to reduce the undesirable side effects associated with NA and hopefully improve the pharmacological effects without inducing any undesirable toxicity.
尽管烟酸（NA）具有多种临床益处，但由于其存在一些不良副作用，如皮肤潮红、胃肠道相关症状等，其功效无法得到充分发挥。为了克服这些问题并提高 NA 的疗效，我们合理设计了一种新型的无机-有机纳米杂化系统。为了制备这种杂化系统，我们通过共沉淀技术将 NA 插入到 LDH 中，然后用 Eudragit S100 对其进行包覆，最终得到了名为 Eudragit S100 包覆 NA-LDH 的药物传递系统。所制备的药物传递系统不仅改善了 NA 的释放特性，而且在 L929 细胞上的生物相容性测试中也表现出良好的生物相容性。这种无机-有机纳米杂化药物递送剂有望降低与 NA 相关的不良副作用，并有望在不引起任何不良毒性的情况下提高其药理作用。
