新生儿脐带血直接染色体分析。
Direct chromosome analysis from neonatal cord blood.
作者信息
Day D W, Jalal S M, Sinclair-Worley L, Kukolich M, Freeman M, Sakakini J
机构信息
Texas Genetic Screening and Counseling Service, Denton 76202-2467.
出版信息
Am J Med Genet. 1988 Dec;31(4):943-6. doi: 10.1002/ajmg.1320310429.
Direct chromosome preparations of neonatal cord blood provides the unique opportunity for rapid chromosome analysis (turnaround time; 6 hr), without the necessity of bone marrow aspiration. Based on 42 samples we confirm the finding of Garnham and Sutherland [1987] for suitability of cord blood for direct chromosome preparation. Procedural modifications are provided for higher yield of cells for chromosome analysis. The procedure may well be of major significance for rapid diagnosis of neonates who suffer from aneusomy.
新生儿脐带血的直接染色体标本制备为快速染色体分析（周转时间为6小时）提供了独特的机会，而无需进行骨髓穿刺。基于42个样本，我们证实了加纳姆和萨瑟兰[1987]关于脐带血适合直接染色体标本制备的发现。文中提供了程序修改方法，以提高用于染色体分析的细胞产量。该程序对于快速诊断患有非整倍体的新生儿可能具有重要意义。
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