Wang Xin, Qiao Wei, Xiao Yangjie, Sun Lijuan, Ren Weidong
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Ultrasound, First Hospital of Qinhuangdao, Qinhuangdao, China.
J Ultrasound Med. 2020 Nov;39(11):2219-2229. doi: 10.1002/jum.15333. Epub 2020 May 12.
In animal models with constrictive pericarditis (CP), detecting the function of cardiac systole by conventional noninvasive ultrasound is a challenge. We aimed to detect cardiac dysfunction in rat models with CP in the early stage by layered speckle tracking.
We compared a rat CP model (n = 23, injected with a solution of 1-mg/mL lipopolysaccharides [0.5 mL] and a 10% talc suspension [0.5 mL]) with a control group (n = 20, no injection). After 8 weeks, conventional echocardiography and layered speckle tracking were used to assess the left ventricular structures and functions in the groups.
The global circumferential strain (CS) and longitudinal strain (LS) were decreased in the CP group (P < .05). The CS of the epicardial and middle layers in the CP group was decreased (P < .05), but the endocardial layer was not statistically different. The LS of the epicardial layer was decreased (P < .05), but the middle and endocardial layers were not statistically different. The global free-wall and septal-wall CS of the CP group was decreased (P < .05), mainly due to the decrease of CS of the epicardial and middle layers. The global free-wall LS of the CP group was decreased (P < .05), mainly due to the decrease of LS of the epicardial and middle layers. There were no significant differences between the groups in global LS of the septal wall.
In the early stage of CP, subepicardial myocardial damage precedes that of the subendocardial myocardium, and free-wall damage precedes that of the septal wall.
在缩窄性心包炎（CP）动物模型中，通过传统的非侵入性超声检测心脏收缩功能是一项挑战。我们旨在通过分层斑点追踪技术在CP大鼠模型早期检测心脏功能障碍。
我们将大鼠CP模型（n = 23，注射1 mg/mL脂多糖溶液[0.5 mL]和10%滑石粉混悬液[0.5 mL]）与对照组（n = 20，未注射）进行比较。8周后，使用传统超声心动图和分层斑点追踪技术评估两组的左心室结构和功能。
CP组的整体圆周应变（CS）和纵向应变（LS）降低（P < 0.05）。CP组的心外膜层和中层的CS降低（P < 0.05），但心内膜层无统计学差异。心外膜层的LS降低（P < 0.05），但中层和心内膜层无统计学差异。CP组的整体游离壁和室间隔壁CS降低（P < 0.05），主要是由于心外膜层和中层CS的降低。CP组的整体游离壁LS降低（P < 0.05），主要是由于心外膜层和中层LS的降低。两组室间隔壁的整体LS无显著差异。
在CP早期，心外膜下心肌损伤先于心内膜下心肌，游离壁损伤先于室间隔壁。
