端粒DNA-RNA杂交G-四链体存在于HeLa细胞的环境条件中。
Telomeric DNA-RNA-hybrid G-quadruplex exists in environmental conditions of HeLa cells.
作者信息
Bao Hong-Liang, Xu Yan
机构信息
Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
出版信息
Chem Commun (Camb). 2020 Jun 18;56(48):6547-6550. doi: 10.1039/d0cc02053b. Epub 2020 May 12.
In the present study, we employed a F NMR approach to study the association of telomere RNA and DNA in vitro and in living human cells. We successfully characterized the DNA-RNA hybrid G-quadruplex (HQ) structure formed by telomeric DNA and RNA. We further demonstrated for the first time that an HQ conformation can exist in the environmental conditions of HeLa cells.
在本研究中，我们采用了一种F核磁共振方法来研究端粒RNA与DNA在体外及活的人类细胞中的关联。我们成功地表征了由端粒DNA和RNA形成的DNA-RNA杂交G-四链体（HQ）结构。我们还首次进一步证明了HQ构象能够存在于HeLa细胞的环境条件中。
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