Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
J Am Chem Soc. 2020 Jun 3;142(22):9890-9895. doi: 10.1021/jacs.0c02121. Epub 2020 May 18.
Described herein is the first iridium-catalyzed cyclative indenylation through sequential B(4)-C and intramolecular C-C bond formation from -carboranes and propargyl alcohols, leading to the formation of B(4)-indenylated -carboranes with excellent regioselectivity via direct B-H activation. Moreover, the iridium-catalyzed regioselective 1,3-dienylation has been accessed through sequential B-H activation, dehydration, and decarboxylation, producing B(4)-dienylated -carboranes.
本文描述了首例铱催化的通过顺序 B(4)-C 和分子内 C-C 键形成的环化茚基化反应，该反应从 -卡硼烷和炔丙醇出发，通过直接 B-H 活化生成具有优异区域选择性的 B(4)-茚基化 -卡硼烷。此外，通过顺序的 B-H 活化、脱水和脱羧反应，还实现了铱催化的区域选择性 1,3-二烯基化反应，生成了 B(4)-二烯基化 -卡硼烷。
