Field Neurosciences Institute laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Epigenomics. 2020 Apr;12(7):647-656. doi: 10.2217/epi-2019-0347. Epub 2020 May 12.
Parkinson's disease (PD) is a neurodegenerative disease with loss of dopaminergic neurons. PD has genetic and epigenetic influences that determine specific changes in the brain. Epigenetic changes result in defective methylation of genes leading to differential gene-expression causing PD. This review provides an overview of stem cell transplantations as potential therapies for PD, with a focus on the epigenetic changes, prior or following transplantation. To date, no reports have addressed epigenetic alterations following stem cell transplantation into the PD brain. Given the potential for affecting the efficacy of stem cell therapy, increased attention needs to be given to the epigenetic processes that occur during stem cell culture and transplantation to maximize the therapeutic potential of stem cells to PD.
帕金森病（PD）是一种神经退行性疾病，其特征是多巴胺能神经元丧失。PD 存在遗传和表观遗传影响，决定了大脑中特定的变化。表观遗传变化导致基因甲基化缺陷，导致 PD 差异基因表达。本综述提供了干细胞移植作为 PD 潜在治疗方法的概述，重点关注移植前后的表观遗传变化。迄今为止，尚无报道涉及干细胞移植到 PD 大脑后是否会发生表观遗传改变。鉴于其可能影响干细胞治疗的效果，需要更加关注干细胞培养和移植过程中发生的表观遗传过程，以最大限度地发挥干细胞治疗 PD 的潜力。
