Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
Department of Physical Therapy, Center for Respiratory Research and Rehabilitation, University of Florida, Gainesville, FL, USA.
J Neurochem. 2021 Jan;156(1):16-37. doi: 10.1111/jnc.15041. Epub 2020 Jun 10.
The Kölliker-Fuse nucleus (KF) is a functionally distinct component of the parabrachial complex, located in the dorsolateral pons of mammals. The KF has a major role in respiration and upper airway control. A comprehensive understanding of the KF and its contributions to respiratory function and dysfunction requires an appreciation for its neurochemical characteristics. The goal of this review is to summarize the diverse neurochemical composition of the KF, focusing on the neurotransmitters, neuromodulators, and neuropeptides present. We also include a description of the receptors expressed on KF neurons and transporters involved in each system, as well as their putative roles in respiratory physiology. Finally, we provide a short section reviewing the literature regarding neurochemical changes in the KF in the context of respiratory dysfunction observed in SIDS and Rett syndrome. By over-viewing the current literature on the neurochemical composition of the KF, this review will serve to aid a wide range of topics in the future research into the neural control of respiration in health and disease.
科尔利克融合核（KF）是脑桥被盖复合体的一个功能独特的组成部分，位于哺乳动物的背外侧脑桥中。KF 在呼吸和上呼吸道控制中起着重要作用。全面了解 KF 及其对呼吸功能和障碍的贡献需要了解其神经化学特征。本综述的目的是总结 KF 的多种神经化学组成，重点介绍存在的神经递质、神经调质和神经肽。我们还描述了 KF 神经元上表达的受体和参与每个系统的转运体，以及它们在呼吸生理学中的潜在作用。最后，我们提供了一个简短的部分，回顾了 SIDS 和雷特综合征中观察到的呼吸功能障碍情况下 KF 神经化学变化的文献。通过综述 KF 神经化学组成的现有文献，本综述将有助于未来研究健康和疾病状态下呼吸的神经控制的广泛主题。
