微生物组为霍乱奠定基础。
The Microbiome Sets the Stage for Cholera.
机构信息
Department of Biology, Indiana University, Bloomington, IN, USA.
Department of Biology, Indiana University, Bloomington, IN, USA.
出版信息
Trends Microbiol. 2020 Jun;28(6):430-432. doi: 10.1016/j.tim.2020.03.002. Epub 2020 Apr 16.
PMID:32396824
Abstract
Interactions between the eukaryotic host, microbiome members, and invading pathogens help to shape disease outcomes. Using the Drosophila model, Fast et al. identified that Vibrio cholerae acts to inhibit epithelial renewal through complex interactions between the type VI secretion system of V. cholerae and the microbial community of the fly.
摘要
真核宿主、微生物群成员和入侵病原体之间的相互作用有助于塑造疾病的结局。Fast 等人利用果蝇模型发现，霍乱弧菌通过其类型 VI 分泌系统与果蝇微生物群落之间的复杂相互作用，来抑制上皮细胞的更新。
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