Host-Microbe-Pathogen Interactions: A Review of Pathogenesis in .

Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen . Over the last decades, our knowledge of pathogenesis, colonization, and transmission has increased tremendously. A number of animal models have been used to study how interacts with host-derived resources to support gastrointestinal colonization. Here, we review studies on host-microbe interactions and how infection with disrupts these interactions, with a focus on contributions from the model. We will discuss studies that highlight the connections between symbiont, host, and metabolism; crosstalk between and host microbes; and the impact of the host immune system on the lethality of infection. These studies suggest that modulates host immune-metabolic responses in the fly and improves fitness through competition with intestinal microbes.