单细胞基因组学时代的神经胶质瘤干细胞模型。
The Glioma Stem Cell Model in the Era of Single-Cell Genomics.
机构信息
Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel.
出版信息
Cancer Cell. 2020 May 11;37(5):630-636. doi: 10.1016/j.ccell.2020.04.001.
Glioma stem cells (GSCs) are thought to underlie glioma initiation, evolution, and resistance to existing therapies. Although functional evidence for GSCs is abundant, tumor heterogeneity and intrinsic limitations in GSC assays have represented barriers for the field. In this perspective, we revisit the GSC model in light of recent single-cell expression profiling studies. We highlight how classes of glioma differ in their cellular architecture and relate the observed cellular states to established GSC markers. We additionally propose a set of single-cell informed definitions as a framework for our understanding of the cellular architecture of gliomas and a potential therapeutic outlook.
神经胶质瘤干细胞（GSCs）被认为是神经胶质瘤发生、演变以及对现有治疗方法产生抗性的根源。尽管有大量关于 GSCs 的功能证据，但肿瘤异质性和 GSC 检测中的内在限制一直是该领域的障碍。在这篇观点文章中，我们根据最近的单细胞表达谱研究重新审视了 GSC 模型。我们强调了不同类型的神经胶质瘤在细胞结构上的差异，并将观察到的细胞状态与已确立的 GSC 标志物联系起来。此外，我们还提出了一组基于单细胞信息的定义，作为我们理解神经胶质瘤细胞结构的框架，以及潜在的治疗前景。
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