Neglia J P, Day D L, Swanson T V, Ramsay N K, Robison L L, Nesbit M E
Department of Pediatrics, University of Minnesota Hospital, Minneapolis 55455.
Am J Pediatr Hematol Oncol. 1988 Winter;10(4):296-300. doi: 10.1097/00043426-198824000-00005.
The prognostic significance of kidney size at diagnosis of acute lymphoblastic leukemia (ALL) was assessed in a population of 142 children. Kidney size was determined using three different methodologies, and its significance was determined by univariate and multivariate life-table methods. Enlarged kidney size (as determined by any of the three methods used) was not associated with an overall poorer survival. These findings were consistent when kidney size at diagnosis was analyzed as a singled variable and when it was considered after adjustment for the known prognostic factors of age, sex, and initial WBC count. Assessment of renal size at the time of diagnosis of childhood ALL is not indicated for the purpose of predicting subsequent prognosis.
在142名儿童群体中评估了急性淋巴细胞白血病（ALL）诊断时肾脏大小的预后意义。使用三种不同方法测定肾脏大小，并通过单变量和多变量生命表法确定其意义。肾脏增大（通过所使用的三种方法中的任何一种确定）与总体较差的生存率无关。当将诊断时的肾脏大小作为单一变量分析时，以及在对年龄、性别和初始白细胞计数等已知预后因素进行调整后考虑时，这些发现是一致的。为预测后续预后而评估儿童ALL诊断时的肾脏大小并无必要。
