文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

载姜黄素的海藻酸钠-阿拉伯胶纳米粒的制备、表征及生物活性筛选。

Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin.

机构信息

Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia.

Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang 43400, Malaysia.

出版信息

Molecules. 2020 May 10;25(9):2244. doi: 10.3390/molecules25092244.

DOI:10.3390/molecules25092244
PMID:32397633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7249151/
Abstract

The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was -15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy.

摘要

载姜黄素的阿拉伯胶-海藻酸钠纳米粒（Cur/ALG-GANPs）的制备及抗氧化和药物释放性能研究。采用离子凝胶技术制备 Cur/ALG-GANPs，并采用衰减全反射傅里叶变换红外光谱（ATR-FTIR）、X 射线衍射（XRD）、差示扫描量热法（DSC）、粒径分布和透射电子显微镜（TEM）对其进行物理化学特性表征。Cur/ALG-GANPs 的粒径在 10±0.3nm 至 190±0.1nm 之间，zeta 电位为-15±0.2mV。Cur/ALG-GANPs 的抗氧化研究表明，其对 1,1-二苯基-2-苦基肼基（DPPH）自由基具有有效的清除能力，浓度范围在 30 至 500μg/mL 之间。采用 MTT 法进行细胞毒性实验，以测量其抑制细胞生长的潜力，结果表明 Cur/ALG-GANPs 对人肝癌细胞（HepG2）具有显著的抗癌活性，优于结肠癌（HT29）、肺癌（A549）和乳腺癌（MCF7）细胞。因此，本研究表明 Cur/ALG-GANPs 具有有前途的抗癌特性，可能有助于未来的癌症治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/728a8a496dc6/molecules-25-02244-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/744652bfaba7/molecules-25-02244-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/8b067eedc11c/molecules-25-02244-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/062418af9339/molecules-25-02244-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/22a9f01d1a30/molecules-25-02244-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/d4a5cb884853/molecules-25-02244-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/88093ea68e1b/molecules-25-02244-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/021221be589b/molecules-25-02244-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/f104f5cc6d8d/molecules-25-02244-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/7a72dd4daa51/molecules-25-02244-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/7a5fdfeda0ac/molecules-25-02244-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/728a8a496dc6/molecules-25-02244-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/744652bfaba7/molecules-25-02244-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/8b067eedc11c/molecules-25-02244-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/062418af9339/molecules-25-02244-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/22a9f01d1a30/molecules-25-02244-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/d4a5cb884853/molecules-25-02244-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/88093ea68e1b/molecules-25-02244-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/021221be589b/molecules-25-02244-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/f104f5cc6d8d/molecules-25-02244-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/7a72dd4daa51/molecules-25-02244-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/7a5fdfeda0ac/molecules-25-02244-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f90/7249151/728a8a496dc6/molecules-25-02244-g011.jpg

相似文献

[1]
Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin.

Molecules. 2020-5-10

[2]
Nanohybrid Based on (Mn, Zn) Ferrite Nanoparticles Functionalized With Chitosan and Sodium Alginate for Loading of Curcumin Against Human Breast Cancer Cells.

AAPS PharmSciTech. 2023-11-7

[3]
Synergistic Effects of Photo-Irradiation and Curcumin-Chitosan/Alginate Nanoparticles on Tumor Necrosis Factor-Alpha-Induced Psoriasis-Like Proliferation of Keratinocytes.

Molecules. 2019-4-9

[4]
Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line.

Curr Drug Deliv. 2018

[5]
Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications.

J Biomater Appl. 2015-11

[6]
Synergistic effect of curcumin and tamoxifen loaded in pH-responsive gemini surfactant nanoparticles on breast cancer cells.

BMC Complement Med Ther. 2024-9-20

[7]
Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration.

Int J Nanomedicine. 2018-12-6

[8]
Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles.

Sci Rep. 2020-10-20

[9]
Nanoparticles based on oleate alginate ester as curcumin delivery system.

Curr Drug Deliv. 2015

[10]
Galactosylated alginate-curcumin micelles for enhanced delivery of curcumin to hepatocytes.

Int J Biol Macromol. 2016-5

引用本文的文献

[1]
Unlocking the therapeutic potential of unexplored phytocompounds as hepatoprotective agents through integration of network pharmacology and in-silico analysis.

Sci Rep. 2025-3-11

[2]
Apoptotic and anti-inflammatory effect of nisin-loaded sodium alginate-gum arabic nanoparticles against colon cancer cells.

Int J Biol Macromol. 2025-5

[3]
Gum Arabic: A Commodity with Versatile Formulations and Applications.

Nanomaterials (Basel). 2025-2-13

[4]
Camellia sinensis methanolic leaves extract: Phytochemical analysis and anticancer activity against human liver cancer cells.

PLoS One. 2024

[5]
Cutting-edge biomaterials for advanced biomedical uses: self-gelation of l-arginine-loaded chitosan/PVA/vanillin hydrogel for accelerating topical wound healing and skin regeneration.

RSC Adv. 2024-9-30

[6]
Alginate Extracted from Loaded in Selenium Nanoparticles: Insight on Characterization, Antifungal and Anticancer Activities.

Polymers (Basel). 2024-7-19

[7]
Pharmacokinetics evaluation of newly formulated beads alginate/gum acacia loaded ketoconazole in rabbit plasma by oral administration.

ADMET DMPK. 2023-11-30

[8]
Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration.

Front Pharmacol. 2024-4-19

[9]
Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers.

Pharmaceutics. 2024-3-21

[10]
Polysaccharide-based hydrogel enriched by epidermal growth factor peptide fragment for improving the wound healing process.

Heliyon. 2023-11-23

本文引用的文献

[1]
Glutathione-responsive nanoparticles based on a sodium alginate derivative for selective release of doxorubicin in tumor cells.

J Mater Chem B. 2017-3-28

[2]
Preparation, Characterization, and In vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles.

AAPS PharmSciTech. 2019-3-18

[3]
Biocompatible disulphide cross-linked sodium alginate derivative nanoparticles for oral colon-targeted drug delivery.

Artif Cells Nanomed Biotechnol. 2019-12

[4]
An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery.

AAPS PharmSciTech. 2019-1-10

[5]
The effect of thiamine-coating nanoparticles on their biodistribution and fate following oral administration.

Eur J Pharm Sci. 2018-11-23

[6]
Applications of nanoparticle systems in drug delivery technology.

Saudi Pharm J. 2018-1

[7]
Green synthesis of sodium alginate-silver nanoparticles and their antibacterial activity.

Int J Biol Macromol. 2018-1-5

[8]
Gum Arabic-encapsulated gold nanoparticles for a non-invasive photothermal ablation of lung tumor in mice.

Biomed Pharmacother. 2017-5

[9]
pH-Sensitive ZnO Quantum Dots-Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery.

ACS Appl Mater Interfaces. 2016-8-19

[10]
Selenium nanoparticles as a nutritional supplement.

Nutrition. 2017-1

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索