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扁平苔藓作为一种可能的罕见眼病病因。

Lichen planus as a possible rare cause of an ocular disease.

作者信息

Nekolová J, Středová M, Podhola M, Jirásková N

出版信息

Cesk Slov Oftalmol. 2019 Winter;75(4):219-223. doi: 10.31348/2019/4/6.

Abstract

Lichen planus is a relatively common mucocutaneous papulosquamous disorder of unknown etiology that is thought to be immunologically mediated. Ocular involvement of lichen planus (LP) is a rare event, which can lead to irreversible damage to the ocular surface and loss of vision from cicatrizing blepharoconjunctivitis and corneal scarring. Steroids are the first treatment choice. Treatment with topical ciclosporin A is also a possible treatment. We report a case of 79-year-old woman who was treated for long lasting severe inflammatory disease of a ocular surface. It led to blindness of one eye and low vision of the second eye. The diagnosis was made thanks to correlation of biopsy results from oral and ocular surface. The patient was also diagnosed with middle-stage dementia. Negative impact of steroid therapy on mental condition of this patient was considered. On the other hand, dementia could cause worse compliance with recommended treatment regime. Chronic inflammatory disease of ocular surface requires long lasting treatment very often and it is sometimes not as effective as expected. Discovering etiological causes of the disease is a priority for the right treatment. We emphasize also the key role of physical and mental condition in management of ocular surface disease.

摘要

扁平苔藓是一种病因不明的相对常见的黏膜皮肤丘疹鳞屑性疾病,被认为是由免疫介导的。扁平苔藓(LP)累及眼部是一种罕见情况,可导致眼表不可逆损伤以及因瘢痕性睑结膜炎和角膜瘢痕形成而丧失视力。类固醇是首选治疗方法。局部使用环孢素A治疗也是一种可行的治疗方法。我们报告一例79岁女性患者,她因长期严重的眼表炎症性疾病接受治疗。这导致一只眼睛失明,另一只眼睛视力低下。通过口腔和眼表活检结果的相关性做出了诊断。该患者还被诊断为中期痴呆。考虑到类固醇治疗对该患者精神状况的负面影响。另一方面,痴呆可能导致对推荐治疗方案的依从性更差。眼表慢性炎症性疾病通常需要长期治疗,而且有时效果不如预期。发现该疾病的病因是正确治疗的首要任务。我们还强调身心状况在眼表疾病管理中的关键作用。

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