错配修复缺陷的结直肠癌中 TIGIT 和 PD-1 的上调。
Upregulation of TIGIT and PD-1 in Colorectal Cancer with Mismatch-repair Deficiency.
机构信息
Department of Medical Laboratory, School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
Department of General Surgery Center, People's Hospital of Ningxia Hui Autonomous region, Yinchuan, China.
出版信息
Immunol Invest. 2021 May;50(4):338-355. doi: 10.1080/08820139.2020.1758130. Epub 2020 May 13.
: The role of T cell Ig and ITIM domain (TIGIT) and programmed cell death-1 (PD-1) in colorectal cancer (CRC) with mismatch repair deficiency is unknown.: This was a study of 60 CRC patients with mismatch repair deficiency and 30 healthy controls between June 2015 and October 2015.: The expression of Foxp3, PD-1, and TIGIT was higher in cancer tissues compared with adjacent mucosa (all < .05). Patients with advanced TNM stage had a significantly higher expression of TIGIT ( = .025) and PD-1 ( = .020) than patients with early-stage CRC. The disease-free survival (DFS) of patients with high TIGIT (HR = 3.96, 95%CI: 1.34-11.69, = .013) or PD-1 (HR = 214.8, 95%CI: 49.88-925.2, < .001) expression were better. The overall survival (OS) of the patients with CRC and high expression of PD-1 was worse than those with low expression (HR = 4.01, 95%CI:1.26-12.69, = .019).: TIGIT and PD-1 are upregulated in CRC with mismatch repair deficiency and associated with TNM stage and DFS.
: T 细胞免疫球蛋白和 ITIM 结构域（TIGIT）和程序性细胞死亡受体 1（PD-1）在错配修复缺陷型结直肠癌（CRC）中的作用尚不清楚。
: 这是一项 2015 年 6 月至 2015 年 10 月期间对 60 例错配修复缺陷型 CRC 患者和 30 例健康对照者进行的研究。
: 与邻近黏膜相比，癌症组织中 Foxp3、PD-1 和 TIGIT 的表达更高（均<0.05）。TNM 晚期患者的 TIGIT（=0.025）和 PD-1（=0.020）表达显著高于早期 CRC 患者。TIGIT 高表达（HR=3.96，95%CI：1.34-11.69，=0.013）或 PD-1 高表达（HR=214.8，95%CI：49.88-925.2，<0.001）的患者无病生存率（DFS）更好。CRC 患者 PD-1 高表达的总生存率（OS）较低表达患者更差（HR=4.01，95%CI：1.26-12.69，=0.019）。
: 错配修复缺陷型 CRC 中 TIGIT 和 PD-1 表达上调，与 TNM 分期和 DFS 相关。
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