Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China.
Nat Med. 2020 Jun;26(6):842-844. doi: 10.1038/s41591-020-0901-9. Epub 2020 May 12.
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8 T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
与 2019 年冠状病毒病（COVID-19）严重程度相关的呼吸道免疫特征目前尚不清楚。我们通过单细胞 RNA 测序对不同严重程度 COVID-19 患者和健康人的支气管肺泡灌洗液免疫细胞进行了特征描述。在重症 COVID-9 患者的支气管肺泡灌洗液中，丰富的促炎单核细胞衍生巨噬细胞。中度病例的特点是存在高度克隆扩增的 CD8 T 细胞。这个支气管肺泡免疫微环境图谱为 COVID-19 的发病机制和恢复提供了潜在的机制。
