COVID-19 患者支气管肺泡免疫细胞的单细胞景观。
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
机构信息
Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China.
出版信息
Nat Med. 2020 Jun;26(6):842-844. doi: 10.1038/s41591-020-0901-9. Epub 2020 May 12.
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8 T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
与 2019 年冠状病毒病（COVID-19）严重程度相关的呼吸道免疫特征目前尚不清楚。我们通过单细胞 RNA 测序对不同严重程度 COVID-19 患者和健康人的支气管肺泡灌洗液免疫细胞进行了特征描述。在重症 COVID-9 患者的支气管肺泡灌洗液中，丰富的促炎单核细胞衍生巨噬细胞。中度病例的特点是存在高度克隆扩增的 CD8 T 细胞。这个支气管肺泡免疫微环境图谱为 COVID-19 的发病机制和恢复提供了潜在的机制。
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