Xu Mengyuan, Chen Tao, Yang Caifei, Meng Xu, Peng Qingyun, Lei Xiaoguang
Department of Neurology, Kunming Medical University, Kunming 650000, China.
Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming 650000, China.
Parkinsons Dis. 2020 Jan 21;2020:5190703. doi: 10.1155/2020/5190703. eCollection 2020.
Freezing of gait (FOG) is a disabling phenomenon that is described by patients with Parkinson's disease (PD). Not only gait may be involved in the freezing phenomenon, but also some nonmotor symptoms, such as freezing of urination (FOU) in this case. The characters of urinary dysfunctions in this case resemble "off" freezing: (1) abrupt difficulty in starting or continuing in urination; (2) the urinary dysfunctions fluctuated with medication state; and (3) the urinary dysfunctions could be alleviated dramatically by an external cueing. Urinary dysfunctions in this patient (and maybe more PD patients) are associated not only with the classical "nonmotor symptoms" but also the freezing phenomenon. FOU could be a part of the spectrum of freezing symptoms. The subtypes of the freezing phenomenon will shed light on the PD pathophysiology and clinical treatment.
冻结步态(FOG)是帕金森病(PD)患者描述的一种致残现象。不仅步态可能参与冻结现象,在这种情况下一些非运动症状也会出现,比如排尿冻结(FOU)。该病例中排尿功能障碍的特征类似于“关期”冻结:(1)排尿起始或持续突然困难;(2)排尿功能障碍随药物状态波动;(3)外部提示可显著缓解排尿功能障碍。该患者(可能更多PD患者)的排尿功能障碍不仅与典型的“非运动症状”有关,还与冻结现象有关。排尿冻结可能是冻结症状谱的一部分。冻结现象的亚型将为帕金森病的病理生理学和临床治疗提供线索。