Yang Huaguang, Liu Weiyin Vivian, Wang Shanshan, Yang Wenbin, Liu Changsheng, Wen Zhi, Hu Lanhua, Guo Jinxia, Fan Guoguang, Luo Xiaoguang, Zha Yunfei
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China.
MR Research, GE Healthcare, Beijing, China.
Front Aging Neurosci. 2022 Apr 8;14:833287. doi: 10.3389/fnagi.2022.833287. eCollection 2022.
Freezing of gait (FOG) is a common gait disturbance phenomenon in multiple system atrophy (MSA) patients. The current investigation assessed the incidence FOG in a cross-sectional clinical study, and clinical correlations associated with it.
Ninety-nine MSA patients from three hospitals in China were consecutively enrolled in the study. Eight patients were subsequently excluded from the analysis due to incomplete information. The prevalence of FOG symptoms in the MSA cohort was determined, and clinical manifestations in MSA patients with and without FOG were assessed.
Of 91 MSA patients, 60 (65.93%) exhibited FOG. The incidence of FOG increased with disease duration and motor severity and was correlated with modified Hoehn and Yahr (H-Y) stages [odds ratio (OR), 0.54; 95% confidence interval (CI), 0.33-3.92], longer disease duration (OR, 0.54, 95% CI, 0.37-0.78), higher Unified Multiple System Atrophy Rating Scale (UMSARS) score (OR, 0.96, 95% CI, 0.93-0.99), MSA-cerebellum subtype (OR, 2.99, 95% CI, 1.22-7.33), levodopa-equivalent dose (LDED) (OR, 0.998, 95% CI, 0.997-1.00), and higher Scale for the Assessment and Rating of Ataxia (SARA) score (OR, 0.80, 95% CI, 0.72-0.89) (logistic regression). Motor dysfunction was significantly positively associated with lower quality of life scores ( < 0.01).
FOG is a common symptom in MSA patients and it is correlated with poor quality of life, disease progression and severity, levodopa-equivalent dose, and cerebellum impairment.
冻结步态（FOG）是多系统萎缩（MSA）患者中常见的步态障碍现象。本研究在一项横断面临床研究中评估了FOG的发生率及其相关的临床关联。
连续纳入来自中国三家医院的99例MSA患者。随后，由于信息不完整，8例患者被排除在分析之外。确定MSA队列中FOG症状的患病率，并评估有和无FOG的MSA患者的临床表现。
在91例MSA患者中，60例（65.93%）出现FOG。FOG的发生率随疾病持续时间和运动严重程度增加，且与改良Hoehn和Yahr（H-Y）分期[比值比（OR），0.54；95%置信区间（CI），0.33 - 3.92]、更长的疾病持续时间（OR，0.54，95% CI，0.37 - 0.78）、更高的统一多系统萎缩评定量表（UMSARS）评分（OR，0.96，95% CI，0.93 - 0.99）、MSA-小脑亚型（OR，2.99，95% CI，1.22 - 7.33）、左旋多巴等效剂量（LDED）（OR，0.998，95% CI，0.997 - 1.00）以及更高的共济失调评估与评分量表（SARA）评分（OR，0.80，95% CI，0.72 - 0.89）相关（逻辑回归）。运动功能障碍与较低的生活质量评分显著正相关（<0.01）。
FOG是MSA患者的常见症状，且与生活质量差、疾病进展和严重程度、左旋多巴等效剂量以及小脑损害相关。
