Attout Hassene, Amichi Sofia, Josse Françoise, Appavoupoule Vincent, Randriajohany Andry, Thirapathi Yogananda
Internal Medicine Unit, General Hospital, Ales, France.
Internal Medicine Unit, GHER, Saint-Benoît, Reunion.
Eur J Case Rep Intern Med. 2020 Mar 27;7(5):001588. doi: 10.12890/2020_001588. eCollection 2020.
Cannabis is one of the most widely used illicit drugs in the world. Its use is associated with several short- and long-term side-effects such as changes in mood, impaired memory, impaired attention, depression and anxiety, and it is correlated with schizophrenia. Cannabinoid hyperemesis syndrome (CHS) is characterized by chronic cannabis use, cyclic intractable nausea and vomiting, and compulsive hot bathing. Patients are typically diagnosed with CHS only after multiple medical evaluations. Recent research has identified type 1 cannabinoid receptors in the intestinal nerve plexus that have an inhibitory effect on gastrointestinal motility. This effect may explain hyperemesis in cannabis users. The thermoregulatory role of endocannabinoids may be responsible for compulsive hot bathing. We describe the cases of two young men seeking repeated emergency room care with recurrent nausea and vomiting. Abstinence from cannabis led to resolution of vomiting symptoms and abdominal pain.
Cannabis is one of the most widely used illicit drugs in world.Cannabinoid hyperemesis syndrome is an under-recognized syndrome that can lead to expensive and unrevealing investigations.Abstinence from cannabis led to resolution of symptoms.
大麻是世界上使用最广泛的非法药物之一。其使用与多种短期和长期副作用相关，如情绪变化、记忆力减退、注意力受损、抑郁和焦虑，并且与精神分裂症有关。大麻素呕吐综合征（CHS）的特征是长期使用大麻、周期性顽固性恶心和呕吐以及强迫性热水浴。患者通常在经过多次医学评估后才被诊断为CHS。最近的研究在肠神经丛中发现了1型大麻素受体，其对胃肠蠕动有抑制作用。这种作用可能解释了大麻使用者的呕吐症状。内源性大麻素的体温调节作用可能是强迫性热水浴的原因。我们描述了两名年轻男性反复因反复恶心和呕吐到急诊室就诊的病例。戒除大麻后呕吐症状和腹痛得到缓解。
大麻是世界上使用最广泛的非法药物之一。大麻素呕吐综合征是一种未被充分认识的综合征，可导致昂贵且无结果的检查。戒除大麻可使症状缓解。
