特发性CD4+ T细胞淋巴细胞减少症：诊断11年后的病例报告

Idiopathic CD4+ T-cell Lymphocytopenia: Report of a Case 11 Years after Diagnosis.

作者信息

Lorenzo Villalba Noel, Zulfiqar Abrar-Ahmad, Maouche Yasmine, Cordoba Sosa Zaida, Alonso Ortiz Maria Belen, Andres Emmanuel

机构信息

Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, France.

Internal Medicine Department, Fuerteventura General Hospital, Fuerteventura, Spain.

出版信息

Eur J Case Rep Intern Med. 2020 Mar 30;7(5):001589. doi: 10.12890/2020_001589. eCollection 2020.

DOI:10.12890/2020_001589

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7213825/

Abstract

UNLABELLED

We report the case of a 23-year-old woman evaluated for asthenia and lymphocytopenia. Clinical examination was unremarkable but laboratory tests showed the presence of CD4 lymphocytopenia. Secondary causes of CD4 lymphocytopenia were ruled out and a previous diagnosis of idiopathic CD4+ T-cell lymphocytopenia was retained. CD4 lymphocytopenia has persisted for 11 years now but the patient has been clinically asymptomatic.

LEARNING POINTS

CD4+ T-cell lymphocytopenia needs to be meticulously evaluated and secondary causes ruled out.The patient has been clinically asymptomatic for 11 years.Measurement of CD4 subsets twice yearly seems to be appropriate.

摘要

未标注

我们报告了一例23岁女性因乏力和淋巴细胞减少前来评估的病例。临床检查无异常，但实验室检查显示存在CD4淋巴细胞减少。排除了CD4淋巴细胞减少的继发原因，维持先前特发性CD4+ T细胞淋巴细胞减少的诊断。CD4淋巴细胞减少至今已持续11年，但患者临床上无症状。

学习要点

CD4+ T细胞淋巴细胞减少需要仔细评估并排除继发原因。该患者已临床无症状11年。每年两次检测CD4亚群似乎是合适的。

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本文引用的文献

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Idiopathic lymphocytopenia.特发性淋巴细胞减少症

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Idiopathic CD4 lymphocytopenia: clinical and immunologic characteristics and follow-up of 40 patients.特发性CD4淋巴细胞减少症：40例患者的临床和免疫学特征及随访

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[Multifocal MALT lymphoma and acute cytomegalovirus gastritis revealing CD4 lymphopenia without HIV infection].[多灶性黏膜相关淋巴组织淋巴瘤及急性巨细胞病毒性胃炎伴CD4淋巴细胞减少但无HIV感染]

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Idiopathic CD4+ T-lymphocytopenia--immunodeficiency without evidence of HIV infection.特发性CD4+ T淋巴细胞减少症——无HIV感染证据的免疫缺陷。

N Engl J Med. 1993 Feb 11;328(6):380-5. doi: 10.1056/NEJM199302113280602.

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