使用超声仪中实现的新系统对脂肪变性和纤维化进行定量分析。

Quantification of Steatosis and Fibrosis using a new system implemented in an ultrasound machine.

机构信息

Department of Gastroenterology and Hepatology, ''Victor Babeș'' University of Medicine and Pharmacy, Timișoara, România.

Department of Gastroenterology and Hepatology, ''Victor Babeș'' University of Medicine and Pharmacy, Timișoara, România Department of Functional Sciences, ''Victor Babeș'' University of Medicine and Pharmacy, Timișoara, România.

出版信息

Med Ultrason. 2020 Sep 5;22(3):265-271. doi: 10.11152/mu-2495. Epub 2020 Apr 4.

DOI:10.11152/mu-2495

PMID:32399537

Abstract

AIM

The study compared the usefulness of 2D-SWE and attenuation measurements obtained using Aplio i800 from Canon together with Transient Elastography (TE) and the Controlled Attenuation Parameter (CAP) as the reference method.

MATERIAL AND METHODS

We included 112 consecutive adults with reliable LS measurements, 44 healthy subjects and 68 subjects with chronic hepatopathies in whom liver stiffness (LS) and steatosis were evaluated in the same session employing two elastography techniques: Transient Elastography (TE) with Controlled Attenuation Parameter (CAP) implemented on the FibroScan® 530 Compact system and Two Dimensional Shear Wave Elastography (2D-SWE) with Attenuation Imaging (ATI) installed on the Aplio i800 series ultrasound system. Reliable measurements were defined as the median value of 10, respectively 5 valid LS measurements for TE and 2D-SWE, with an interquartile range interval/median ratio (IQR/M) <30%.

RESULTS

A very strong positive correlation was found between LS values obtained by TE and 2D-SWE: r=0.88, p<0.0001 and between the attenuation coefficients of steatosis obtained by CAP and ATI, r=0.81, p<0.0001. The best cut-off values by 2DSWE for predicting different stages of liver fibrosis were: for F≥2 - 7.9 kPa and F=4 - 11.7 kPa. Regarding steatosis, the best ATI cut-off values were: for S≥1 - 0.79 dB/cm/mHz and for S3 - 0.86 dB/cm/mHz.

CONCLUSION

2D-SWE and ATI measurements with the new system strongly correlated with TE and CAP results.

摘要

目的

本研究比较了佳能 Aplio i800 上的 2 维剪切波弹性成像（2D-SWE）和衰减测量与瞬时弹性成像（TE）和受控衰减参数（CAP）的实用性，后者作为参考方法。

材料和方法

我们纳入了 112 例具有可靠 LS 测量值的连续成年患者，其中 44 例为健康受试者，68 例为慢性肝病患者，在同一次检查中使用两种弹性成像技术评估肝脏硬度（LS）和脂肪变性：瞬时弹性成像（TE）结合受控衰减参数（CAP），在 FibroScan® 530 Compact 系统上实施；二维剪切波弹性成像（2D-SWE）结合衰减成像（ATI），在 Aplio i800 系列超声系统上安装。可靠的测量定义为 TE 和 2D-SWE 的 10 次或 5 次有效 LS 测量值的中位数，IQR/M<30%。

结果

TE 和 2D-SWE 获得的 LS 值之间存在非常强的正相关：r=0.88，p<0.0001，CAP 和 ATI 获得的脂肪变性衰减系数之间存在非常强的正相关：r=0.81，p<0.0001。2D-SWE 预测不同阶段肝纤维化的最佳截断值为：F≥2-7.9 kPa，F=4-11.7 kPa。关于脂肪变性，最佳 ATI 截断值为：S≥1-0.79 dB/cm/mHz，S3-0.86 dB/cm/mHz。