以瞬时弹性成像为参考方法，评估二维剪切波弹性成像（2D-SWE.GE）预测肝纤维化不同阶段的性能。

Performance of 2D-SWE.GE for predicting different stages of liver fibrosis, using Transient Elastography as the reference method.

作者信息

Bende Felix, Sporea Ioan, Sirli Roxana, Popescu Alina, Mare Ruxandra, Miutescu Bogdan, Lupusoru Raluca, Moga Tudor, Pienar Corina

机构信息

University of Medicine and Pharmacy "Victor Babes" Timisoara.

出版信息

Med Ultrason. 2017 Apr 22;19(2):143-149. doi: 10.11152/mu-910.

DOI:10.11152/mu-910

PMID:28440347

Abstract

AIM

To evaluate the performance of 2D shear-wave elastography from General Electric (2D-SWE.GE) for the noninvasiveassessment of liver fibrosis and to identify liver stiffness (LS) cut-off values for predicting different stages of fibrosisusing Transient Elastography (TE) as the reference method.

MATERIAL AND METHOD

We included 331 consecutive subjectswith or without chronic hepatopathies in whom LS was evaluated in the same session by means of 2 elastographic techniques:TE and 2D-SWE.GE. Reliable LS measurements were defined for TE as the median value of 10 measurements with a successrate of ≥60% and an interquartile range (IQR)<30% and for 2D-SWE.GE as the median value of 10 measurements acquiredin a homogenous area and an IQR<30%. To discriminate between TE fibrosis stages we used the following cut-offs: F2- 7;F3- 9.5 and F4- 12kPa.

RESULTS

Reliable LS measurements were obtained in 95.8% subjects by 2D-SWE.GE, and 94.2%by TE (p=0.44). Based on TE cut-off values we divided our cohort into four groups: F<2: 30.1%; F=2: 10.2%; F=3: 12.2%;F=4: 47.5%. A strong correlation was found between the LS values obtained by the 2 methods: r=0.83, p<0.0001.LS valuesobtained by 2D-SWE.GE were significantly lower than those obtained by TE: 10.14±4.24 kPa vs. 16.72±13.4 kPa (p<0.0001).The best cut-off value for F≥2, F≥3 and for F=4 were 6.7, 8.2 and 9.3 kPa.

CONCLUSIONS

The best 2D-SWE.GE cut-off valuesfor predicting F≥2, F≥3 and F=4 were 6.7, 8.2 and 9.3kPa.

摘要

目的

评估通用电气公司的二维剪切波弹性成像技术（2D-SWE.GE）在肝纤维化无创评估中的性能，并以瞬时弹性成像技术（TE）作为参考方法，确定预测不同纤维化阶段的肝脏硬度（LS）临界值。

材料与方法

我们纳入了331例有或无慢性肝病的连续受试者，在同一时间段内通过两种弹性成像技术对其肝脏硬度进行评估：TE和2D-SWE.GE。对于TE，可靠的LS测量值定义为10次测量的中位数，成功率≥60%且四分位间距（IQR）<30%；对于2D-SWE.GE，可靠的LS测量值定义为在均匀区域采集的10次测量的中位数且IQR<30%。为区分TE纤维化阶段，我们采用以下临界值：F2 - 7；F3 - 9.5和F4 - 12kPa。

结果

2D-SWE.GE在95.8%的受试者中获得了可靠的LS测量值，TE为94.2%（p = 0.44）。根据TE临界值，我们将研究队列分为四组：F<2：30.1%；F = 2：10.2%；F = 3：12.2%；F = 4：47.5%。两种方法获得的LS值之间存在强相关性：r = 0.83，p<0.0001。2D-SWE.GE获得的LS值显著低于TE获得的值：10.14±4.24 kPa对16.72±13.4 kPa（p<0.0001）。预测F≥2、F≥3和F = 4的最佳临界值分别为6.7、8.2和9.3 kPa。