McGeer P L, Itagaki S, Akiyama H, McGeer E G
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
Ann Neurol. 1988 Oct;24(4):574-6. doi: 10.1002/ana.410240415.
It has been hypothesized that idiopathic parkinsonism might be due to age-related attrition of dopamine neurons occurring long after an initial acute episode. We present evidence against this hypothesis, based on our finding of at least six times as many HLA-DR-positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control brains. This difference indicates an active pathological process.
有假说认为，特发性帕金森病可能是由于在最初的急性发作后很长时间才出现的与年龄相关的多巴胺能神经元损耗所致。基于我们的发现，帕金森病患者大脑中吞噬多巴胺能神经元的HLA - DR阳性小胶质细胞数量至少是对照大脑中的六倍，我们提出了反对这一假说的证据。这种差异表明存在一个活跃的病理过程。
