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马蹄金叶提取物通过抑制认知功能障碍、氧化应激和炎症反应来减轻糖尿病性神经病变。

Gongronema latifolium Benth. leaf extract attenuates diabetes-induced neuropathy via inhibition of cognitive, oxidative stress and inflammatory response.

机构信息

Department of Biochemistry, Landmark University, Omu-Aran, Kwara State, Nigeria.

Phytomedicine and Nutraceutical Research Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.

出版信息

J Sci Food Agric. 2020 Sep;100(12):4504-4511. doi: 10.1002/jsfa.10491. Epub 2020 Jun 8.

Abstract

BACKGROUND

Gongronema latifolium (G. latifolium) Benth. leaves are traditionally used to treat diabetes mellitus (DM) and other diseases in Nigeria and West Africa. This study was performed to evaluate the neuroprotective effect of aqueous extract of G. latifolium leaf against DM. Antidiabetic activity of G. latifolium extracts (6.36, 12.72 and 25.44 mg kg , i.p.) was determined in alloxan-induced diabetic rats. Fasting blood glucose level and oxidative stress markers catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), and nitric oxide (NO) levels were measured. Cognitive biomarkers acetylcholinesterase (AChE), butyrylcholinesterase (BChE), dopamine (DOPA), serotonin, epinephrine and norepinephrine and cyclooxygenase (COX-2) were measured in the brain of controls and of G. latifolium-treated diabetic rats.

RESULTS

Administration of G. latifolium leaf extract to diabetic rats significantly restored the alterations in the levels of fasting blood glucose (FBG). The MDA and NO levels were significantly reduced with an improvement in CAT, SOD, and GPx activity in the kidneys and brains of diabetic rats treated with G. latifolium. Gongronema latifolium also significantly decreased the levels of AChE, BChE, DOPA, serotonin, epinephrine, and nor-epinephrine in diabetic rats. G. latifolium effectively ameliorated COX-2 in diabetic rats.

CONCLUSION

This study showed that leaf extract of G. latifolium improved antioxidant defense against oxidative stress. It displays a neuroprotective effect resulting in the modulation of brain neurotransmitters, which could be considered as a promising treatment therapy. © 2020 Society of Chemical Industry.

摘要

背景

在尼日利亚和西非,琴叶榕(G. latifolium)的叶子被传统用于治疗糖尿病(DM)和其他疾病。本研究旨在评估琴叶榕叶水提物对 DM 的神经保护作用。用链脲佐菌素(alloxan)诱导的糖尿病大鼠来测定琴叶榕提取物(6.36、12.72 和 25.44 mg/kg,ip)的抗糖尿病活性。测定空腹血糖水平和氧化应激标志物过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)、丙二醛(MDA)和一氧化氮(NO)水平。测定对照组和琴叶榕治疗的糖尿病大鼠大脑中的乙酰胆碱酯酶(AChE)、丁酰胆碱酯酶(BChE)、多巴胺(DOPA)、血清素、肾上腺素和去甲肾上腺素和环加氧酶(COX-2)等认知生物标志物。

结果

给予琴叶榕叶提取物可显著恢复糖尿病大鼠空腹血糖(FBG)水平的改变。琴叶榕治疗的糖尿病大鼠肾脏和大脑中的 MDA 和 NO 水平显著降低,CAT、SOD 和 GPx 活性得到改善。琴叶榕还显著降低了糖尿病大鼠中 AChE、BChE、DOPA、血清素、肾上腺素和去甲肾上腺素的水平。琴叶榕可有效改善糖尿病大鼠中的 COX-2。

结论

本研究表明,琴叶榕叶提取物可改善抗氧化防御,对抗氧化应激。它具有神经保护作用,可调节大脑神经递质,可作为一种有前途的治疗方法。

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