N-乙酰神经氨酸对香烟烟雾所致黏液纤毛运输功能受损的影响。
The effect of N-acetylneuraminic acid on the mucociliary transport impaired by cigarette smoke.
作者信息
Miyata T, Matsumoto N, Yuki H, Takahama K, Okano Y, Kai H
机构信息
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
出版信息
Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:202-9.
PMID:3240018
Abstract
Cigarette smoke exposure impaired the mucociliary transport on the tracheal mucosa of pigeons. N-acetylneuraminic acid (NANA), but not lactose, dose-dependently protected against the impairment of the mucociliary transport. The results suggest that NANA, a representative sialic acid existing on the airway epithelium, may participate the defence mechanism in the respiratory tract against irritant gases.
摘要
接触香烟烟雾会损害鸽子气管黏膜的黏液纤毛运输功能。N-乙酰神经氨酸（NANA）而非乳糖，能剂量依赖性地保护黏液纤毛运输功能免受损害。结果表明，作为气道上皮细胞上存在的一种代表性唾液酸，NANA可能参与呼吸道针对刺激性气体的防御机制。
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