候选 microRNA 的表达研究及其作为糖尿病周围神经病变生物标志物的潜在应用评估。
Expression study of candidate miRNAs and evaluation of their potential use as biomarkers of diabetic neuropathy.
机构信息
UniCamillus - Saint Camillus International University of Health Sciences, Rome, Italy.
Department of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, Rome, Italy.
出版信息
Epigenomics. 2020 Apr;12(7):575-585. doi: 10.2217/epi-2019-0242. Epub 2020 May 13.
To evaluate the expression of candidate miRNAs in relation to diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN). The expression of six candidate miRNAs has been evaluated in 49 Type 2 diabetes patients with neurological evaluation. A higher expression of miR-128a was seen in patients with DPN compared with those without DPN (p = 0.015). miR-155 and miR-499a seemed to be down-expressed in patients with DPN (p = 0.04 and p = 0.05, respectively). A lower expression of miR-155 (p = 0.05) was observed even in patients with CAN with respect to CAN-negative. A higher expression of miR-155 was associated with the rs767649 polymorphism variant allele compared with the wild-type allele (p = 0.03). miR-128a, miR-155 and miR-499a might be involved in diabetic neuropathies development.
为了评估候选 miRNA 与糖尿病多发性神经病变 (DPN) 和心血管自主神经病变 (CAN) 的关系表达。在 49 名接受神经学评估的 2 型糖尿病患者中，评估了 6 种候选 miRNA 的表达。与无 DPN 的患者相比，DPN 患者的 miR-128a 表达更高 (p = 0.015)。miR-155 和 miR-499a 似乎在 DPN 患者中表达下调 (p = 0.04 和 p = 0.05)。与 CAN 阴性患者相比，甚至在伴有 CAN 的患者中也观察到 miR-155 的低表达 (p = 0.05)。与野生型等位基因相比，miR-155 的 rs767649 多态性变异等位基因的表达更高 (p = 0.03)。miR-128a、miR-155 和 miR-499a 可能参与糖尿病神经病变的发生。
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