Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Acta Otolaryngol. 2020 Aug;140(8):706-711. doi: 10.1080/00016489.2020.1758342. Epub 2020 May 13.
Sinonasal squamous cell carcinoma (SCC) is a rare tumor arising either or in association with inverted papillomas (IPs). The aim of this study was to investigate and compare the oncological features and prognosis of patients with sinonasal SCCs based on their etiology. The medical records of 117 patients who had been diagnosed with SCC or those arising from IP (IP-SCC) were retrospectively reviewed. hybridization analyses to detect HPV 16/18DNA and p16 immunohistochemistry were also performed in 10 cases with IP-SCC. The three-year disease-specific survival (DSS) rate was higher in cases with T1, 2 and 3 than in cases with T4 in both tumor groups. T4 cases with SCC had a better DSS than those with IP-SCCs. HPV16/18 was not detected in any of the 10 IP-SCCs. T4 cases with SCC tended to have a better DSS than those with IP-SCC. Since some T4 patients with IP-SCC were found to have a highly aggressive disease, careful treatment planning should be performed. High-risk HPV may not play a vital role in the carcinomatous transformation of most IP-SCC cases.
鼻窦鳞状细胞癌 (SCC) 是一种罕见的肿瘤，可原发于鼻窦或与内翻性乳头状瘤 (IP) 相关。本研究旨在根据病因探讨和比较鼻窦 SCC 患者的肿瘤学特征和预后。回顾性分析了 117 例诊断为鼻窦 SCC 或源自 IP 的 SCC (IP-SCC) 患者的病历。对 10 例 IP-SCC 患者进行了 HPV 16/18DNA 的原位杂交分析和 p16 免疫组化染色。在两组肿瘤中，T1、2 和 3 期患者的 3 年疾病特异性生存率 (DSS) 均高于 T4 期患者。T4 期鼻窦 SCC 患者的 DSS 优于 IP-SCC 患者。在 10 例 IP-SCC 中均未检测到 HPV16/18。T4 期鼻窦 SCC 患者的 DSS 优于 IP-SCC 患者。由于一些 T4 期 IP-SCC 患者表现出侵袭性较强的疾病，应谨慎制定治疗计划。高危型 HPV 可能在大多数 IP-SCC 病例的癌变过程中不起关键作用。
