Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences Mashhad, Iran.
Curr Pharm Des. 2020;26(34):4277-4284. doi: 10.2174/1381612826666200513112607.
Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receiving attention for the management of periodontitis owing to their general safety and efficacy. Curcumin, a bioactive polyphenol extracted from Curcuma longa, has been shown to possess antioxidant, antimicrobial, anti-inflammatory and analgesic properties. Several studies have assessed the efficacy of curcumin against periodontal diseases. These studies have shown equivalent or even higher efficacy of curcumin compared to the commonly used medications for the management of periodontitis such as chlorhexidine. Herein, we review the experimental and clinical findings on the anti-periodontitis effects of curcumin and the pharmacological mechanisms underlying these effects.
牙周病是成年人牙齿丧失的最常见原因之一。研究表明，炎症是牙周炎发生和发展的关键因素之一。由于草药的安全性和有效性普遍较高，最近它们受到了治疗牙周炎的关注。姜黄素是从姜黄中提取的一种生物活性多酚，具有抗氧化、抗菌、抗炎和镇痛特性。多项研究评估了姜黄素治疗牙周病的疗效。这些研究表明，与用于治疗牙周炎的常用药物（如洗必泰）相比，姜黄素具有等效甚至更高的疗效。在此，我们综述了姜黄素抗牙周炎作用的实验和临床研究结果及其作用机制。
