稳定与连接：LARP7 在核非编码 RNA 代谢中的作用。
Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism.
机构信息
Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany.
Department of Biochemistry, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany.
出版信息
RNA Biol. 2021 Feb;18(2):290-303. doi: 10.1080/15476286.2020.1767952. Epub 2020 Jun 3.
Abstract
La and La-related proteins (LARPs) are characterized by a common RNA interaction platform termed the La module. This structural hallmark allows LARPs to pervade various aspects of RNA biology. The metazoan LARP7 protein binds to the 7SK RNA as part of a 7SK small nuclear ribonucleoprotein (7SK snRNP), which inhibits the transcriptional activity of RNA polymerase II (Pol II). Additionally, recent findings revealed unanticipated roles of LARP7 in the assembly of other RNPs, as well as in the modification, processing and cellular transport of RNA molecules. Reduced levels of functional LARP7 have been linked to cancer and Alazami syndrome, two seemingly unrelated human diseases characterized either by hyperproliferation or growth retardation. Here, we review the intricate regulatory networks centered on LARP7 and assess how malfunction of these networks may relate to the etiology of LARP7-linked diseases.
摘要
La 及其相关蛋白（LARPs）的特征是存在一个共同的 RNA 相互作用平台，称为 La 模块。这一结构特征使 LARPs 能够渗透到 RNA 生物学的各个方面。真核生物的 LARP7 蛋白作为 7SK 小核核糖核蛋白（7SK snRNP）的一部分与 7SK RNA 结合，从而抑制 RNA 聚合酶 II（Pol II）的转录活性。此外，最近的研究发现 LARP7 在其他 RNP 的组装以及 RNA 分子的修饰、加工和细胞运输中具有意想不到的作用。功能性 LARP7 水平降低与癌症和 Alazami 综合征有关，这两种看似无关的人类疾病要么表现为过度增殖，要么表现为生长迟缓。在这里，我们综述了以 LARP7 为中心的复杂调控网络，并评估了这些网络的功能障碍如何与 LARP7 相关疾病的病因学相关。
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