这些变体影响高海拔地区中国人群的 NSCLC 风险。
variants influence NSCLC risk in the Chinese population in a high altitude area.
机构信息
Department of Medicine Oncology, The Fifth People's Hospital of Qinghai Province, Xining, Qinghai, China.
Department of Medicine Oncology, The Affiliated Hospital of Qinghai University, Xining, Qinghai, China.
出版信息
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620918192. doi: 10.1177/1753466620918192.
BACKGROUND
Non-small cell lung cancer (NSCLC) accounts for approximately 80% of diagnosed lung cancer patients. has been reported to be associated with the development of squamous cell lung carcinoma. In this study, we assessed the relationships of genetic polymorphisms and NSCLC risk among the Chinese population at high altitude.
METHODS
Eight single nucleotide polymorphisms (SNPs) of were genotyped in the Agena MassARRAY platform among 506 NSCLC patients and 510 healthy controls. We examined the association of polymorphisms with NSCLC risk using odds ratios (ORs) and 95% confidence intervals (CIs) multiple genetic models.
RESULTS
The rs10774474 A allele was related to a decreased risk of NSCLC in a high altitude population of China (OR = 0.82, 95% CI = 0.69-0.98, = 0.032), whereas mutant alleles of rs1051672, rs7310449, rs1051669, rs6413436, rs4766377 and rs10849605 significantly increased NSCLC risk. Haplotype analysis showed that four haplotypes of polymorphisms conferred an enhanced susceptibility to NSCLC (AGTA: OR = 1.29, = 0.021; GACG: OR = 1.21, = 0.027; GCTC: OR = 1.26, = 0.032; ACAT: OR = 1.21, = 0.032).
CONCLUSIONS
Our findings suggested the remarkable association of polymorphisms with NSCLC risk among the Chinese population in a high altitude area.
背景
非小细胞肺癌（NSCLC）约占确诊肺癌患者的 80%。已报道其与鳞状细胞肺癌的发展有关。在这项研究中，我们评估了 基因多态性与中国高海拔地区人群 NSCLC 风险的关系。
方法
在 Agena MassARRAY 平台上对 506 例 NSCLC 患者和 510 例健康对照者的 进行了 8 个单核苷酸多态性（SNP）的基因分型。我们使用比值比（OR）和 95%置信区间（CI），采用多种遗传模型，检验了 多态性与 NSCLC 风险的关联。
结果
rs10774474 的 A 等位基因与中国高海拔人群 NSCLC 的风险降低相关（OR=0.82，95%CI=0.69-0.98，P=0.032），而 rs1051672、rs7310449、rs1051669、rs6413436、rs4766377 和 rs10849605 的突变等位基因显著增加了 NSCLC 的风险。单倍型分析表明， 基因多态性的 4 种单倍型增加了 NSCLC 的易感性（AGTA：OR=1.29，P=0.021；GACG：OR=1.21，P=0.027；GCTC：OR=1.26，P=0.032；ACAT：OR=1.21，P=0.032）。
结论
我们的研究结果表明， 基因多态性与中国高海拔地区人群 NSCLC 风险显著相关。
Zotero 插件