Department of Medicine Oncology, The Fifth People's Hospital of Qinghai Province, Xining, Qinghai 810007, P.R. China.
Department of Medicine Oncology, The Affiliated Hospital of Qinghai University, Xining, Qinghai 810016, P.R. China.
Oncol Rep. 2021 Mar;45(3):1295-1305. doi: 10.3892/or.2021.7935. Epub 2021 Jan 14.
Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑related deaths worldwide. Cisplatin‑based chemotherapy currently represents the main treatment option for patients with NSCLC. The aim of the present study was to evaluate effect of single nucleotide polymorphisms (SNPs) within the excision repair cross‑complementing group 5 (ERCC5) gene on susceptibility to NSCLC, as well as the responsiveness to and toxicity of cisplatin chemotherapy. A total of 506 patients with NSCLC and 510 healthy controls were recruited for the present study. All DNA samples were genotyped by the Agena MassARRAY platform. Logistic regression analysis was carried out to assess the relationship between ERCC5 polymorphisms with NSCLC susceptibility and responsiveness to chemotherapy. The rs4771436 TG‑GG genotype was associated with increased NSCLC risk. When the data were stratified according to age, sex, tobacco smoking, body mass index and histological type, ERCC5 polymorphisms (rs2016073, rs4771436, rs11069498 and rs4150330) were associated with NSCLC risk. Furthermore, the A allele and GA‑AA genotype of rs11069498 were related to the response to chemotherapy. ERCC5 (rs11069498 and rs4150330) polymorphisms were associated with the increased risk of toxicity. However, rs4771436 in ERCC5 gene was significantly correlated with the reduced risk of toxicity. These results suggested a potential relationship between ERCC5 polymorphisms, the risk of NSCLC and the sensitivity to cisplatin‑based chemotherapy among Chinese populations.
非小细胞肺癌（NSCLC）是全球癌症相关死亡的主要原因。基于顺铂的化疗目前是 NSCLC 患者的主要治疗选择。本研究旨在评估切除修复交叉互补组 5（ERCC5）基因内的单核苷酸多态性（SNP）对 NSCLC 易感性的影响，以及对顺铂化疗的反应性和毒性。本研究共纳入 506 例 NSCLC 患者和 510 例健康对照者。所有 DNA 样本均通过 Agena MassARRAY 平台进行基因分型。采用 logistic 回归分析评估 ERCC5 多态性与 NSCLC 易感性和化疗反应性之间的关系。rs4771436TG-GG 基因型与 NSCLC 风险增加相关。当根据年龄、性别、吸烟、体重指数和组织学类型对数据进行分层时，ERCC5 多态性（rs2016073、rs4771436、rs11069498 和 rs4150330）与 NSCLC 风险相关。此外，rs11069498 的 A 等位基因和 GA-AA 基因型与化疗反应相关。ERCC5（rs11069498 和 rs4150330）多态性与毒性增加的风险相关。然而，rs4771436 在内的 ERCC5 基因与毒性降低的风险显著相关。这些结果表明，在中国人群中，ERCC5 多态性与 NSCLC 风险和对基于顺铂的化疗的敏感性之间存在潜在关系。
